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SERUM URIC ACID LEVELS IN METABOLIC SYNDROME

PRIYA A

Abstract


BACKGROUND Metabolic Syndrome (MetS) is  defined as a cluster of metabolic and cardiovascular disturbances, such as central obesity, hypertension,  dyslipidemia and hyperglycemia. The prevalence of Metabolic syndrome varies around the World which reflects the age and ethnicity of the study populations and the defining diagnostic criteria. Its prevalence increases with advancing age, highest in the age group of 45 to 49 years. In South India, the prevalence of MetS is 26.9 percent in males and 18.4 percent in females. Serum uric acid levels is reported to be associated with factors that contribute to insulin resistance and metabolic syndrome. AIMS AND OBJECTIVES To estimate the levels of serum uric acid in patients with metabolic syndrome and to compare with healthy subjects and to correlate it with Fasting Plasma Glucose(FPG), Triglycerides (TGL), High Density   Lipoprotein-Cholesterol (HDL) and Waist Circumference(WC). MATERIALS AND METHODS This cross-sectional study was conducted at MGMGH attached to K.A.P.V Govt. Medical  College,Trichy during June to October 2015. Study group  included 50 individuals of metabolic syndrome as per Modified NCEP ATP III 2005 criteria and 50 healthy controls. Blood  pressure, Fasting plasma glucose, Lipid profile, Uric acid, and Anthropometric measures were determined. RESULTS Serum uric acid was significantly higher in MetS group (mean 5.98 in males and 5.2 in females) than non-MetS group (mean 5.1 in males and 4.2 and in females ) (p 0.001). In Pearson correlation analysis, serum uric acid levels was positively correlated with WC, BP, FPG, and TGL in both males and females (p 0.001), and negatively with HDL in males and females (p 0.001). CONCLUSION The present study demonstrated that serum uric acid levels are significantly increased in persons with Metabolic Syndrome and it had an independent association with                 components of Metabolic Syndrome. The increase in serum uric acid levels are progressive as the number of components of Metabolic syndrome increases. The association of uric acid and Metabolic Syndrome components supports that it might be an additional component to define Metabolic Syndrome.

 


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