A Cross Sectional Study of Metabolic Derangements in Adolescents with Polycystic Ovary Syndrome in a Tertiary Care Hospital

Abstract

Polycystic ovary syndrome is a commonest    endocrinopathy of women. The prevalence of metabolic  syndrome in women with PCOS appears to be significantly higher than their age matched controls. The consequence of PCOS extend beyond the reproductive age group. The burden of metabolic disturbance in adolescents with PCOS is yet to be explored. In this light of knowledge a cross sectional study of 50 adolescents with PCOS, recruited from gynecological outpatient department of Coimbatore medical college hospital was done for a period of 6 months. The adolescents within the age group if 16-18 years were selected according to     Rotterdam criterion. They were compared with age and BMI matched controls. Aim of this study was to investigate the metabolic abnormalities in adolescent with PCOS and to evaluate the role of obesity as an independent indicator for the development of metabolic abnormalities in adolescents with PCOS. The results showed that the prevalence of   pre-diabetes, insulin resistance, hyperinsulinemia,     dyslipidemia and metabolic syndrome in adolescents with PCOS were more when compared to their age and BMI matched counterparts. PCOS subjects with BMI & gt; 85th centile had high prevalence of pre-diabetes, insulin  resistance, hyperinsulinemia, dyslipidemia and metabolic syndrome when compared with PCOS subjects with BM I & lt; 85th centile. Adolescents with PCOS had more metabolic abnormalities than their age- and BMI-matched non-PCOS counterparts. Obesity could worsen insulin resistance,  hyperinsulinemia and metabolic syndrome in PCOS              adolescents.