SPINAL LYMPHOMA
Abstract
Lymphoma is a lymphoreticular neoplasm primarily arises in extraskeletal location and
skeletal involvement is secondary.skeletal lymphoma commonly seen at thoracic , lumbar and
cervical spine.Primary bone lymphoma (PBL) comprises less than 5 percentage of all malignant bone
tumors and almost 7 percentage of all extranodal lymphomas. Only 1.7 percentage of all PBLs have
been reported to involve the vertebrae. In Hodgkin's lymphoma, approximately 90 percentage of the
cases originate from lymph nodes, whereas 10 percentage arise from extranodal regions. In less than
0.25 percentage of patients with Hodgkin's disease there is primary extranodal
presentation.Extranodal non-Hodgkin's lymphoma (NHL) accounts for 24-48 percentage of all NHL,
while PSEL comprises 0.9 percentage of all extranodal NHLs. Clinicllay they present with pain and
neurological manifestation. In skeletal Hodgkin s lymphoma shows vertebral sclerosis where as NHL
shows permeative distruction is common. In our case patient presented with numbness on both lower
limbs for 4days. Xray revealed paravertebral soft tissue density of D7 with decreased vertebral height
. MRI shows altered marrow signal intensity with paravertebral and epidural soft tissue intensity lesion
appears T1 hypointense and T2 hyperintense compressing the spinal cord at D7 level. Similar lesion
also seen at L5 vertebra. Spinal lymphoma described in this study is a rare presentation with present
MRI findings of marrow signal intensity and soft tissue abnormality and epidural component with
sequale of mass effect on spinalcord.
Full Text:
PDFReferences
Levitt LJ, Dawson DM, Rosenthal DS, Moloney WC: CNS involvement in the non-Hodgkin's
lymphomas. Cancer 1980: 45(3): 545-52.
Boukobza M, Mazel C, Touboul E. Primary vertebral and spinal epidural non-Hodgkin's lymphoma
with spinal cord compression.Neuroradiology. 1996;38:333–7
Li MH, Holtas S, Larsson EM. MR imaging of spinal lymphoma.Acta Radiol. 1992;133:338–42.
[Pubmed]
Ho L, Valenzuela D, Negahban A, Wassef H. Primary spinal epidural non-Hodgkin lymphoma
demonstrated by FDG PET/CT.Clin Nucl Med. 2010;35:487–9.
Otter R, Gerritis WB, Sandt MM, Hermans J, Willemze R. Primary extranodal and nodal non-
Hodgkin's lymphoma. Eur J Cancer Clin Oncol.
Becker J, Venbrocks R. Primary non-Hodgkin lymphoma of the spine. Arch Orthop Trauma Surg.
;117:299–401.
Refbacks
- There are currently no refbacks.
This work is licensed under a Creative Commons Attribution-NoDerivatives 4.0 International License.
An initiative of The Tamil Nadu Dr M.G.R. Medical University