Cover Image




Castleman's disease (CD) is regarded as a  polyclonal lymphoid proliferation of unknown etiology with synonyms of giant node hyperplasia, angiomatous lymphoid hamartoma, angiofollicular lymph node hyperplasia and  follicular lymphoreticuloma. CD may occur anywhere along the lymphatic system with the majority of the cases seen in the mediastinum (70). Extrathoracic sites have been reported in the axilla, neck, pelvis, retroperitoneum, mesentery, central nervous system, and orbit .Here we report a case of   unicentric castlemans disease mimicking intrapulmonary  malignancy.


Full Text:



Slotwiner A, Garwacki CP, Moll S. Castleman's disease. Am J Hematol 2003;73:64-5.

Olscamp G, Weisbrod G, Sanders D, Delarue N, Mustard R. Castleman disease: Unusual manifestations of an unusual disorder. Radiology 1980;135:43-8.

Bowne WB, Lewis JJ, Filippa DA, Niesvizky R, Brooks AD, Burt ME, et al. The management of unicentric and multicentric Castleman's disease: A report of 16 cases and a review of the literature.Cancer 1999;85:706-17.

Snead MP, James JN, Snead DR, Robson DK, Rizk SN. Orbital lymphomas and Castleman's disease. Eye (Lond) 1993;7:84-8.

Castleman B, Towne VW. Case records of the massachusetts general hospital: case 40011. N Engl J Med 1954;250:26-30.

Tey HL, Tang MB. A case of paraneoplastic pemphigus associated with Castleman's disease presenting as erosive lichen planus. Clin Exp Dermatol 2009;34:e754-6.

Flendrig JA. Benign giant lymphoma: Clinicopathologic correlation study. In: Clark RL, Cumly RW, editors. The Year Book of Cancer. Chicago: Yearbook Medical Publishers; 1970. p. 296-9

Keller AR, Hochholzer L, Castleman B: Hyaline-vascular and plasma-cell types of giant lymph node hyperplasia of the mediastinum and other locations.Cancer. 1972;29:670-683.

Peterson BA, Frizzera G. Multicentric Castleman's disease. Semin Oncol 1993;20:636-47.


  • There are currently no refbacks.

Creative Commons License
This work is licensed under a Creative Commons Attribution-NoDerivatives 4.0 International License.

An Initiative of The Tamil Nadu Dr MGR Medical University