Cover Image

RUPTURED LIVER ADENOMATOSIS - Report of a rare case

SATHISH DEVA KUMAR MURUGESANS

Abstract


Solitary hepatic adenoma is a rare tumor
and adenomatosis of liver is even rarer.
Liver adenomatosis was first recognized
by Flejou et al as more than 10 adenomas
in otherwise normal liver. Although a
benign disease, liver adenomatosis can
be associated with potentially fatal complications
such as spontaneous bleeding
due to rupture and malignant transformation.
The natural history, etiology, optimal
management and prognosis are not yet
well defined due to rarity of the disease.
However, most authors recommend surgical
removal of large or complicated tumor
in symptomatic patient whereas,
close follow-up in asymptomatic patients
with small tumor. We report a 31-year old
lady who was found to have 8 adenomas
in otherwise normal liver. She presented
with sudden onset abdominal pain secondary
to spontaneous bleeding due to
rupture. Hematoma evacuation and right
hepatectomy was done and her follow-up
has been uneventful and symptom-free.


Full Text:

PDF

References


Flejou JF, Barge J, Menu Y, et al.

Liver adenomatosis. An entity distinct

from liver adenoma? Gastroenterology

; 89:1132–1138.

Chiche L, Thong D, Salame E, et al.

Liver adenomatosis: reappraisal, diagnosis,

and surgical management. Ann

Surg 2000; 23:74–81

Ribeiro A, Burgart LJ, Nagorney

DM, Gores GJ. Management of liver

adenomatosis: results with a conservative

surgical approach. Liver

Transpl Surg 1998; 4:388-98

Foster JH, Berman MM. The malignant

transformation of liver cell adenomas.

Arch Surg 1994; 129:712-7

Kawakatsu M, Vilgrain V, Belghiti J,

et al. Association of multiple liver cell

adenomas with spontaneous intrahepatic

portohepatic shunt. Abdom

Imaging 1994; 19(5):438–440.

Bacq Y, Jacquemin E, Balabaud C,

et al. Familial liver adenomatosis associated

with hepatocyte nuclear factor

inactivation. Gastroenterology.

; 125:1470–1475.

Reznik Y, Dao T, Coutant R, et al.

Hepatocyte nuclear factor-1 alpha

gene inactivation: cosegregation between

liver adenomatosis and diabetes

phenotypes in two maturity-onset

diabetes of the young (MODY) 3

families. J Clin Endocrinol Metab.

;89:1476–1480.

Brunt EM, Wolverson MK, Di Bisceglie

AM. Benign hepatocellular tumors

(adenomatosis) in nonalcoholic

steatohepatitis: a case report. Semin

Liver Dis 2005; 25: 230–6.

Grazioli L, Federle MP, Ichikawa T,

Balzano E, Nalesnik M, Madariaga J.

Liver adenomatosis: clinical, histopathologic,

and imaging ndings in 15

patients. Radiology 2000; 216: 395–


Refbacks

  • There are currently no refbacks.


Creative Commons License
This work is licensed under a Creative Commons Attribution-NoDerivatives 4.0 International License.

An Initiative of The Tamil Nadu Dr MGR Medical University