SPINAL INTRADURAL EXTRAOSSEOUS EWINGS SARCOMA - A CASE REPORT
Abstract
Extraosseous Ewings sarcoma (EES)
involving the central nervous system is
rare. We present an unusual case of a
primary extraosseous Ewings sarcoma
arising from the spinal intradural extramedullary
space, based on imaging,
histopathological, and immunohistochemistry.
A 15-year-old girl was admitted
in the hospital with both lower limb
pain for 3 months and weakness of both
lower limbs for 2 months. Our provisional
diagnosis based on clinical and radiological
investigation was an intradural extramedullary
space occupying lesion extending
from D11 to S1 probably a malignant
peripheral nerve sheath tumor or
lymphoma. Since we thought of malignant
lesion we proceeded with biopsy of
the lesion through laminectomy at D12
level. Histopathologically reported as Ewings
tumor and that was confirmed with
immunohistochemistry study CD 99.The
patient was treated with
Chemo and radiotherapy.It has been reported
that extraosseous cases of Ewings
tumor is rare and reported in extradural or
paravertebral area but intradural Ewings
tumor is quite rare.
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PDFReferences
Davison EV, Pearson AD, Emslie J, Reid
MM, Malcolm A, Craft AW. Chromosome
abnormalities in Ewing’s sarcoma.J Clin
Pathol 1989; 42: 797–799.
Delattre O, Zucman J, Melot T, et al.
The Ewing family of tumors—a subgroup
of small-round-cell tumors defined by specific
chimeric transcripts.N Engl J Med 1994;
: 294–299.
Jaffe N, Traggis D, Sallan S, Cassady
R. Improved outlook for Ewing’s sarcoma
with combination chemotherapy
(vincristine, actinomycin D and cyclophosphamide)
and radiation therapy. Cancer
; 38: 1925–1930.
Isefuku, S., Seki, M., Tajino, T., Hakozaki,
M., Asano, S., Hojo, H., Hatori,
M., Tohoku J. Exp.
Med., 2006, 209(4), 369-377.Ewing’s
Sarcoma in the Spinal Nerve Root : A
case report and review of Literature
National Cancer Institute. U.S. National
Institutes of Health. Phase III
Randomized Study of Interval-
Compressed Versus Standard Chemotherapy
in Patients With Newly Diagnosed,
Localized Ewing's Sarcoma
or Peripheral Primitive Neuro - ectodermal
Tumor http://www.cancer.gov/
clinicaltrials/COG-AEWS0031 Last
accessed January 17, 2011.
Uesaka T, Amano T, Inamura T, et
al. Intra - dural, extramedullary spinal
Ewing's sarcoma in childhood. J
Clin Neurosci 2003;10: 122-5.
Weil RJ, Zhuang Z, Pack S, et al.
Intramedullary Ewing sarcoma of the
spinal cord: consequences of molecular
diagnostics. Case report. J Neurosurg
;95:270-5.
Zagar TM, Triche TJ, Kinsella
TJ.Extraosseous Ewing's sarcoma: 25
years later. J Clin Oncol 2008;26:4230
-2.
Pathobiologic Markers of the Ewing
Sarcoma Family of Tumors:State of the
Art and Prediction of Behaviour.Alfredo
Pinto,Paul Dickman,and David Parham.
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