Radiation induced carcinosarcoma of the skin - a case report
Abstract
Sarcoma developing within the field of
the radiation (Radiation induced sarcoma
- RIS) is a late effect of ionising radiation.
Multi-agent treatment including chemotherapy
and radiation are being increasingly
included in the treatment of cancer.
RIS is an uncommon tumour with an incidence
of less than 1 for patients with
cancer who are treated with radiation
and survive 5 years1. Little doubt exists
that the benefits of ionizing radiation far
outweigh the potential risks of developing
sarcomas. Due to paucity of experience
and literature of this rare tumor, the optimal
management is not standardized
and the role of adjuvant radiation and
chemotherapy is not defined. However
local, regional and distant recurrences
have been seen and treatment seems
best judged by the clinical presentation.
This case has been presented for its
rarity and for being the first documented
case of a carcinosarcoma arising in previously
radiated skin.
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Sarcoma developing within the field of
the radiation (Radiation induced sarcoma
- RIS) is a late effect of ionising radiation.
Multi-agent treatment including chemotherapy
and radiation are being increasingly
included in the treatment of cancer.
RIS is an uncommon tumour with an incidence
of less than 1 for patients with
cancer who are treated with radiation
and survive 5 years1. Little doubt exists
that the benefits of ionizing radiation far
outweigh the potential risks of developing
sarcomas. Due to paucity of experience
and literature of this rare tumor, the optimal
management is not standardized
and the role of adjuvant radiation and
chemotherapy is not defined. However
local, regional and distant recurrences
have been seen and treatment seems
best judged by the clinical presentation.
This case has been presented for its
rarity and for being the first documented
case of a carcinosarcoma arising in previously
radiated skin.
Brown TJ , Tschen JA. Primary carcinosarcoma
of the skin: report of a case and
review of the literature. Dermatol Surg.
Jun;25(6):498-500.
Rouas L , Amrani M, Regragui A,
Gamra L, Bellabas MA. Carcinosarcoma
of the skin. Ann Dermatol Venereol. 2006
Apr;133(4):362-5.
Enzinger FM, Weiss SW. General
considerations. In: Soft Tissue Tumors.
rd ed. St. Louis:. Mosby;1995
Bjerkehagen B, Smeland S, Walberg
L, Skjeldal S, Hall KS, Nesland JM, et al.
Radiation-induced sarcoma: 25-year experience
from the Norwegian Radium
Hospital. Acta Oncol. 2008;47(8):1475-82
Nicolas MM, Nayar R, Yeldandi A, De
Frias DV. Pulmonary metastasis of a
postradiation breast epithelioid angiosarcoma
mimicking adenocarcinoma. A case
report. Acta Cytol. Nov-Dec 2006;50
(6):672-6.
Hanasono MM, Osborne MP, Dielubanza
EJ, Peters SB, Gayle LB. Radiation-
induced angiosarcoma after mastectomy
and TRAM flap breast reconstruction.
Ann Plast Surg. Feb 2005;54(2):211-
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