Pancreatic Neuro-Endocrine Tumor A Case Report Review of Literature

Abstract

A 14-year-old boy was evaluated for a
large mass in the head of pancreas and
underwent Whipples procedure with
saphenous vein patch repair of the Superior
mesenteric-portal vein confluence.
The final histo-pathology report was a
well differentiated neuroendocrine carcinoma
of the pancreas. The clinical presentation,
operative post operative management
is discussed.Pancreatic Neuro-
Endocrine Tumors(PNETs) are rare malignancies
and compared to adenocarcinomas
they have an indolent course with
better prognosis. Malignant PNETs constitute
one percent of pancreatic cancers
by incidence 10 percent of pancreatic
cancers by prevalence. They are clinically
classified as non-functioning functioning
tumors (hormonomas). The mainstay
of treatment is complete excision.
Pathological features, Immunohistochemical
studies genetic analysis play a
role in the management of these tumors
with recent developments in the management
of advanced tumors with targeted
therapy,
somatostatin analogues biological agents.