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MULTIPLE INTRACRANIAL MYELOID SARCOMAS- A CASE REPORT

MARIA SUBISON SOOSAIFERNAND

Abstract


We report unusual case of 4 year old
female child with right orbital swelling,
right cerebellar space occupying(SOL)
lesion, midline frontal SOL and hydrocephalus.
Initially, right ventriculo peritoneal(
VP) shunt and biopsy from the orbital
swelling done ,which was reported
as non-Hodgkins lymphoma(NHL) but
IHC and further haematological evaluations
were found to be negative for
NHL.As patient deteriorated further because
of posterior fossa SOL, occipital
craniectomy and total excision of posterior
fossa SOL done. Now the biopsy
was reported as myeloid sarcoma with
positive CD 117 and myeloperoxidase
and on examining the blood and bone
marrow it was found that she was having
Acute Myeloid Leukaemia (AML) M 2
type. Myeloid sarcoma itself is a rare tumour.
In this case it is multiple. Multiple
intra cranial myeloid sarcomas are even
rare among all reported cases.


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References


Roth M.J., Medeiros L.J., Elenitoba-

Johnson K., Kuchnio M., Jaffe E.S., Stetler-

Stevenson(1995) Extramedullary myeloid

cell tumors. An immunohistochemical study

of 29 cases using routinely fixed and processed

paraffin-embedded tissue sections.

Arch Pathol Lab Med 119: 790–798.

Vardiman J.W., Thiele J., Arber D.A.,

Brunning R.D., Borowitz M.J., Porwit A.,

et al. (2009) The 2008 revision of the

World Health Organization (WHO) classification

of myeloid neoplasms and

acute leukemia: Rationale and important

changes. Blood 114: 937–951.

Audouin J, Comperat E, Le Tourneau

A, Camilleri-Broët S, Adida C, Molina

T,Diebold J. Myeloid sarcoma: clinical

and morphologic criteria useful for diagnosis.

Int J Surg Pathol. 2003 Oct;11

(4):271-82.

Dock G. Chloroma and its relationship

to leukemia. Am J Med Sci. 1983;

:152- 16.

Edgerton A. E. Chloroma: Report of a

case and review of the literature. Trans

Am Ophthalol Soc 1947; 45:376.

Chang CC, Eshoa C, Kampalath B,

Shidham VB, Perkins S. Immunophenotypic

profile of myeloid cells in granulocytic

sarcoma by immunohistochemistry.

Correlation with blast differentiation

in bone marrow. Am J Clin Pathol 2000;

:807-811.

Zhang PJ, Barcos M, Stewart CC,

Block AW, Sait S, Brooks JJ. Immunoreactivity

of MIC2 (CD99) in acute myelogenous

leukemia and related disease.

Mod Pathol 2000; 13:452-458.

Hirose Y, Masaki Y, Shimoyama K,

Sugai S, Nojima T. Granulocytic sarcoma

of megakaryoblastic differentiation

in the lymph nodes terminating as

acute megakaryoblastic leukemia in a

case of chronic idiopathic myelofibrosis

persisting for 16 years. Eur J Haematol

; 67:194-198

Tanigawa M, Tsuda Y, Amemiya T, Yamada

K, Nakayama M, Tsuji Y. Orbital tumor

in acute myeloid leukemia associated

with karyotype 46,XX,t(8;21)(q22;q22): A

case report. Ophthalmologica 1998;

:202-205.

Byrd JC, Edenfield WJ, Shields DJ,

Dawson NA. Extramedullary myeloid cell

tumors in acute nonlymphocytic leukemia:

a clinical review. J Clin Oncol. 1995;

:1800-1816.

Byrd JC, Weiss RB, Arthur DC, Lawrence

D, Baer MR, Davey F, Trikha ES,

Carroll AJ, Tantravahi R, Qumsiyeh M,

Patil SR, Moore JO, Mayer RJ, Schiffer

CA, Bloomfield CD. Extramedullary leukemia

adversely affects hematologic complete

remission rate and overall survival in

patients with t(8;21)(q22;q22): Results from

Cancer and Leukemia Group B 8461. J

Clin Oncol 1997; 15:466-475.


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