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Role of Tgf-Beta Pathway in the Pathogenesis of Oral Submucous Fibrosis and its Malignant Transformation- A Review

Subramanian Kuzhali .

Abstract


Oral submucous fibrosis (OSMF) is a potentially malignant disorder with an altered collagen metabolism. Transforming Growth Factor-beta (TGF-β) is a well-known profibrogenic cytokine, has been implicated in the over production of extracellular matrix (ECM) proteins and collagen in many fibrotic diseases including OSMF. The role of TGF-β signaling pathway is crucial in the pathogenesis of OSMF and its malignant transformation.This short review discusses about the TGF-β isoforms, signaling pathways, fibrogenic effects and its potential role in the malignant transformation of OSMF.

Keywords: oral submucous fibrosis, malignant transformation, TGF-β

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References


Ekanayaka RP, Tilakaratne WM. Oral Submucous Fibrosis: Reviewon Mechanisms of Pathogenesis and Malignant Transformation. J CarcinogMutagen2013;S5: 002. doi:10.4172/2157-2518.S5-002

Patil S, Doni B, Maheshwari S. Prevalence and distribution of oral mucosal lesions in a geriatric Indian population. Can Geriatr J 2015; 18:11-15.

Shih YH, Wang TH, Shieh TM, Tseng YH. Oral Submucous Fibrosis: A Review on Etiopathogenesis, Diagnosis, and Therapy. Int J Mol Sci. 2019 Jun 16;20(12):2940. doi: 10.3390/ijms20122940. PMID: 31208114; PMCID: PMC6627879.

Rajalalitha P, Vali S (2005) Molecular pathogenesis of oral submucous fibrosis-a collagen metabolic disorder. J Oral Pathol Med 34: 321-328

Weiss A, Attisano L. The TGF beta superfamily signaling pathway. Wiley Interdiscip Rev Dev Biol. 2013;2(1):47-63.

Murphy-Ullrich, J.E., Suto M J. Thrombospondin-1 regulation oflatent TGF-β activation: A therapeutic target for fibrotic disease. MatrixBiol 2018. 68-69:28–43. https://doi.org/10.1016/j.matbio.2017.12.009

Shi M, Zhu J, Wang R, Chen X, Mi L, Waltz T, Springer TA. Latent TGF-ß structure and activation. Nature.2011 Jun 15;474(7351):343-9.PMID:21677751;PMCID:PMC471672.

Biernacka A, Dobaczewski M, Frangogiannis NG. TGF-ß signaling in fibrosis. Growth Factors. 2011 Oct;29(5):196-202.

Frangogiannis NG. Transforming growth factor–β in tissue fibrosis. J. Exp. Med. 2020 Feb13; 217(3): e20190103./doi.org/10.1084/jem.20190103.PMID:3997468.

Yanjia H, Xinchun J (2007) The role of epithelial-mesenchymal transition inoral squamous cell carcinoma and oral submucous fibrosis. Clin Chim Acta383: 51-56.

Meng XM, Nikolic-Paterson DJ, Lan HY. TGF-ß: the master regulator of fibrosis. Nat Rev Nephrol. 2016 Jun;12(6):325-38.

Maria S., Kamath V.V., Satelur K., Rajkumar K. Evaluation of transforming growth factor beta 1 gene in oral submucous fibrosis induced in Sprague-Dawley rats by injections of areca nut and pan masala (commercial areca nut product) extracts. J Canc Res Therapeut.2016;12:379–385

Chang JZ, Yang WH, Deng YT, Chen HM, Kuo MY EGCG blocksTGFβ1-induced CCN2 by suppressing JNK and p38 in buccal fibroblasts. ClinOral Investig 2013;17: 455-461.

Pang X, Tang YL, Liang XH.Transforming growth factor β signaling in head and neck squamous cell carcinoma: Insights into cellular responses. Oncol Lett 2018;16(4):4799-4806

Meng W, Xia Q, Wu L, Chen S, He X, Zhang L, et al. Downregulation of TGF-betareceptor types II and III in oral squamous cell carcinoma and oral carcinoma-associated fibroblasts. BMC Cancer 2011;11:88.

Yang Y, Ye WL, Zhang RN et al. The Role of TGF-β Signaling Pathways in Cancer and its Potential as a Therapeutic Target. Evid Based Complement Alternat Med 2021;Jul22:6675208.

Pal SK, Thi C, Nguyen K, Morita K, Miki Y, Kayamori K, et al. THBS1 is inducedby TGFB1 in the cancer stroma and promotes invasion of oral squamous cellcarcinoma. J Oral Pathol Med 2016;45:730–9.

Moutasim K A, KarenJ V S, Daniel M, Weinreb P H., et al. Betel-derived alkaloid up-regulates keratinocytealphavbeta6 integrin expression and promotes oral submucous fibrosis. J Pathol 2011; 223: 366-377.

Rajendran R, Harish RK, Anil S, Vidyadharan R, Banerjee M Transforming growth factor-β-1 polymorphisms are infrequent but exist atselected loci in oral submucous fibrosis. Indian J Dent Res 2010; 21: 413-419.

Kale A.D., Mane D.R., Shukla D. Expression of transforming growth factor β and its correlation with lipodystrophy in oral submucous fibrosis: an immunohistochemical study. Med Oral Patol Oral Cir Bucal. 2013;18:e12–18

Bishen KA, Radhakrishnan R, Satyamoorthy K (2008) The role of basicfibroblast growth factor in oral submucous fibrosis pathogenesis. J Oral PatholMed 37: 402-411.

Khan I., Kumar N., Pant I., Narra S., Kondaiah P. Activation of TGF-β pathway by areca nut constituents: a possible cause of oral submucous fibrosis. PloS One. 2012;7

Kamath V.V., Krishnamurthy S., Satelur K.P., Rajkumar K. Transforming growth factor-β1 and TGF-β2 act synergistically in the fibrotic pathway in oral submucous fibrosis: an immunohistochemical observation. Indian J Med Paediatr Oncol. 2015;36:111–116Z

Illeperuma RP, Ryu MH, Kim KY, Tilakaratne WM, Kim J Relationship of fibrosis and the expression of TGF-ß1, MMP-1, andTIMP-1 with epithelial dysplasia in oral submucous fibrosis. Oral Med Pathol 2010. 15(1):21-28

Rai A, Ahmed T, Parveen S, Parveen S, Fiazan MI, Ali S. Expression of transforming growth factor beta in oral submucous fibrosis. J Oral Biol Craniofac Res 2020 Apr-Jun;10(2):168-70

Angadi PV, Krishnapillai R Evaluation of PTEN immunoexpression inoral submucous fibrosis: role in pathogenesis and malignant transformation.Head Neck Pathol2012;6: 314-321.


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