Oral Microbiome in Health and Periodontal Disease- A Review

Packiaraj Selvajothi, Nallasivam Lavanya .

Abstract


Oral microbiome, oral microbiota or oral microflora refers to the microorganisms found in the human oral cavity. Understanding the oral microbiome in health and disease will give further directions to explore the functional and metabolic alterations associated with the diseased states. This review article is an attempt to explain the different aspects of the oral microbiome in health and periodontal disease.

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Cho I, Blaser MJ. The human microbiome: at the interface of health and disease. Nat Rev Genet. 2012 Mar 13;13(4):260-70. doi: 10.1038/nrg3182. PMID: 22411464; PMCID: PMC3418802.

Grice EA, Segre JA. The human microbiome: our second genome. Annu Rev Genomics Hum Genet. 2012;13: 151-70. doi: 10.1146/annurev-genom-090711-163814. Epub 2012 Jun 6. PMID: 22703178; PMCID: PMC3518434.

Behrouzi A, Nafari AH, Siadat SD. The significance of microbiome in personalized medicine. Clin Transl Med. 2019 May 13;8(1):16. doi: 10.1186/s40169-019-0232-y. PMID: 31081530; PMCID: PMC6512898.

Gao L, Xu T, Huang G, Jiang S, Gu Y, Chen F. Oral microbiomes: more and more importance in oral cavity and whole body. Protein Cell. 2018 May;9(5):488-500. doi: 10.1007/s 13238-018-0548-1. Epub 2018 May 7.PMID: 29736705; PMCID:PMC5960472.

Palmer RJ Jr. Composition and development of oral bacterial communities. Periodontol 2000. 2014 Feb;64(1):20-39. doi: 10.1111/ j.1600-0757. 2012.00453.x. PMID: 24320954; PMCID: PMC3876289.

Chandki R, Banthia P, Banthia R. Biofilms: A microbial home. J Indian Soc Periodontol. 2011 Apr;15(2):111-4. doi: 10.4103/ 0972-124X.84377. PMID: 21976832; PMCID:PMC3183659.

Marsh PD. Dental plaque as a biofilm and a microbial community - implications for health and disease. BMC Oral Health. 2006 Jun 15;6 Suppl 1(Suppl 1):S14. doi: 10.1186/ 1472-6831-6-S1-S14. PMID: 16934115; PMCID: PMC2147593.

Sharma N, Bhatia S, Sodhi AS, Batra N. Oral microbiome and health. AIMS Microbiol. 2018 Jan 12;4(1):42-66. doi: 10.3934/microbiol.2018.1.42. PMID: 31294203; PMCID: PMC6605021.

Deo PN, Deshmukh R. Oral microbiome: Unveiling the fundamentals. J Oral Maxillofac Pathol. 2019 Jan-Apr ;23(1):122-128. doi: 10.4103/jomfp. JOMFP_304_18. PMID: 31110428; PMCID: PMC6503789.

Roberts FA, Darveau RP. Microbial protection and virulence in periodontal tissue as a function of polymicrobial communities: symbiosis and dysbiosis. Periodontol 2000. 2015 Oct; 69(1):18-27. doi: 10.1111/prd.12087. PMID: 26252399; PMCID: PMC4530467.

https:/ /www.hmpdacc.org/ reference_ genomes /reference _ genomes.php

Solbiati J, Frias-Lopez J. Metatranscriptome of the Oral Microbiome in Health and Disease. Journal of Dental Research. 2018 May; 97(5):492-500.

Jorth, Peter & Turner, Keith & Meric Gumus, Pinar & Nizam, Nejat & Buduneli, Nurcan & Whiteley, Marvin. (2014). Metatranscriptomics of the Human Oral Microbiome during Health and Disease. mBio. 5. 10.1128/m Bio.01012-14.

Willis JR, Gabaldón T. The Human Oral Microbiome in Health and Disease: From Sequences to Ecosystems. Microorganisms. 2020 Feb 23;8(2):308. doi: 10.3390/microorganisms8020308. PMID: 32102216; PMCID: PMC7074908.

Zaura, E., Keijser, B.J., Huse, S.M. et al. Defining the healthy "core microbiome" of oral microbial communities. BMC Microbiol 9, 259 (2009).

Bik EM, Long CD, Armitage GC, et al. Bacterial diversity in the oral cavity of 10 healthy individuals. ISME J. 2010;4(8):962‐974.

Avila M, Ojcius DM, Yilmaz O. The oral microbiota: living with a permanent guest. DNA Cell Biol. 2009 Aug;28(8):405-11. doi: 10.1089/dna.2009.0874. PMID: 19485767; PMCID: PMC2768665.

Brockhurst MA, Morgan AD, Fenton A, Buckling A. Experimental coevolution with bacteria and phage. The Pseudomonas fluorescens -- Phi2 model system.Infect Genet Evol. 2007; 7(4):547‐552.

Abt MC, Pamer EG. Commensal bacteria mediated defenses against pathogens. Curr Opin Immunol. 2014;29:16‐22.

Emerson, B., Kolm, N. Species diversity can drive speciation. Nature 434, 1015–1017 (2005).

Parahitiyawa NB, Scully C, Leung WK, Yam WC, Jin LJ, Samaranayake LP. Exploring the oral bacterial flora: current status and future directions. Oral Dis. 2010;16(2):136‐145.

.22. Turnbaugh PJ, Ley RE, Hamady M, Fraser-Liggett CM, Knight R, Gordon JI. The human microbiome project. Nature. 2007 Oct 18;449(7164):804-10. doi: 10.1038/nature06244. PMID: 17943116; PMCID:PMC3709439

Horz HP, Meinelt A, Houben B, Conrads G. Distribution and persistence of probiotic Streptococcus salivarius K12 in the human oral cavity as determined by real-time quantitative polymerase chain reaction. Oral Microbiol Immunol. 2007;22(2):126‐130.

Filoche S, Wong L, Sissons CH. Oral biofilms: emerging concepts in microbial ecology. J Dent Res. 2010;89(1):8‐18.

Dewhirst FE, Chen T, Izard J, et al. The human oral microbiome. J Bacteriol. 2010;192(19):5002‐5017.

MF Zarco, TJ Vess, GS Ginsburg. The oral microbiome in health and disease and the potential impact on personalized dental medicine. Volume18, Issue2. March 2012Pages 109-120

Rosier BT, De Jager M, Zaura E, Krom BP. Historical and contemporary hypotheses on the development of oral diseases: are we there yet? Front Cell Infect Microbiol. 2014 Jul 16;4:92. doi: 10.3389/fcimb.2014.00092. PMID: 25077073; PMCID: PMC4100321.

Loesche WJ. The specific plaque hypothesis and the antimicrobial treatment of periodontal disease. Dent Update. 1992;19(2):68‐74

Marsh PD. Microbial ecology of dental plaque and its significance in health and disease. Adv Dent Res.1994;8(2):263‐271.

Hajishengallis G, Lamont RJ. Beyond the red complex and into more complexity: the polymicrobial synergy and dysbiosis (PSD) model of periodontal disease etiology. Mol Oral Microbiol. 2012;27(6):409‐419.

Munson MA, Pitt-Ford T, Chong B, Weightman A, Wade WG. Molecular and cultural analysis of the microflora associated with endodontic infections [published correction appears in J Dent Res. 2003 Jan;82(1):69] [published correction appears in J Dent Res. 2003 Mar;82(3):247]. J Dent Res. 2002;81(11):761‐766.

Boutaga K, van Winkelhoff AJ, Vandenbroucke-Grauls CM, Savelkoul PH. Comparison of real-time PCR and culture for detection of Porphyromonas gingivalis in subgingival plaque samples. J Clin Microbiol. 2003 Nov;41(11):4950-4. doi: 10.1128/jcm.41.11.4950-4954.2003. PMID: 14605122; PMCID: PMC262485.

Mason MR, Nagaraja HN, Camerlengo T, Joshi V, Kumar PS. Deep sequencing identifies ethnicity-specific bacterial signatures in the oral microbiome. PLoS One. 2013 Oct 23;8(10):e77287. doi: 10.1371/journal.pone.0077287. Erratum in: PLoS One. 2014;9(6):e99933. PMID: 24194878; PMCID: PMC3806732.

Mason MR, Preshaw PM, Nagaraja HN, Dabdoub SM, Rahman A, Kumar PS. The subgingival microbiome of clinically healthy current and never smokers. ISME J. 2015 Jan;9(1):268-72. doi: 10.1038/ismej.2014.114. Epub 2014 Jul 11. PMID: 25012901; PMCID: PMC4274424.

Marsh PD. Are dental diseases examples of ecological catastrophes?. Microbiology. 2003;149(Pt 2):279‐294.

Berglundh T, Zitzmann NU, Donati M. Are peri‐implantitis lesions different from periodontitis lesions? J Clin Periodontol 2011; 38 (Suppl. 11): 188–122.

Kumar PS, Mason MR, Brooker MR, O'Brien K. Pyrosequencing reveals unique microbial signatures associated with healthy and failing dental implants. J Clin Periodontol. 2012 May;39(5):425-33. doi: 10.1111/j.1600-051X.2012.01856.x. Epub 2012 Mar 14. PMID: 22417294; PMCID: PMC3323747.

Salvi GE, Aglietta M, Eick S, Sculean A, Lang NP, Ramseier CA. Reversibility of experimental peri-implant mucositis compared with experimental gingivitis in humans. Clin Oral Implants Res. 2012;23(2):182‐190.

Pihlstrom BL, Michalowicz BS, Johnson NW. Periodontal diseases. Lancet. 2005;366 (9499):1809‐1820.

Patel S, Goyal A. The current trends and future perspectives of prebiotics research: a review. 3 Biotech. 2012 Jun;2(2):115–25

Dashiff A, Kadouri DE. Predation of oral pathogens by Bdellovibrio bacteriovorus 109J. Mol Oral Microbiol. 2011;26(1):19‐34

Essche, Mark & Loozen, Gitte & Godts, Christof & Boon, Nico & Pauwels, Martine & Quirynen, Marc & Teughels, Wim. (2012). Bacterial Antagonism Against Periodontopathogens. Journal of periodontology. 84. 10.1902/jop.2012.120261.

Philip D. Marsh, David A. Head & Deirdre A. Devine (2014) Prospects of oral disease control in the future – an opinion, Journal of Oral Microbiology, 6:1.

Lamont RJ, Koo H, Hajishengallis G. The oral microbiota: dynamic communities and host interactions. Nat Rev Microbiol. 2018 Dec;16(12):745-759. doi: 10.1038/s41579-018-0089-x. PMID: 30301974; PMCID: PMC6278837.


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