Transient Leukopenia in Post-Burn Patients Treated with Topical Silver Sulfadiazine Cream- A Retrospective Study

Rahul Gorka, Ashish Kumar Gupta, Gohil .

Abstract


Silver sulfadiazine is commonly used as a topical cream in burn wound management. Transient leukopenia is a known phenomenon in early post-burn period. The total l eukocyte count as well as neutrophil count drop, but recover within 2-3 days. We observed leukopenia in only five out of sixty two patients with thermal injury early in the course of topical treatment with silver sulfadiazine. Leukopenia in burn patients on treatment with topical silver sulfadiazine                 application is currently seen as a harmless, self-limited            phenomenon. It needs further case control and randomized controlled studies for clarifying its actual cause.

 Keywords:  Silver sulfadiazine; leukopenia

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References


Fox CL, Modak SM. Mechanism of Silver Sulfadiazine Action on Burn Wound Infections. Antimicrob Agents Chemother. 1974 Jun;5(6):582–8.

Silver sulfadiazine--a new topical therapy for Pseudomonas in burns. Therapy of Pseudomonas infection in burns. - PubMed - NCBI [Internet]. [cited 2017 Jul 2]. Available from: https://www.ncbi.nlm.nih.gov/pubmed/5638080

Chan CK, Jarrett F, Moylan JA. Acute leukopenia as an allergic reaction to silver sulfadiazine in burn patients. J Trauma. 1976 May;16(5):395–6.

Valente P, Axelrod JL. Acute leukopenia associated with silver sulfadiazine therapy. J Trauma. 1978 Feb;18(2):146–7.

Caffee HH, Bingham HG. Leukopenia and silver sulfadiazine. J Trauma. 1982 Jul;22(7):586–7.

Jarrett F, Ellerbe S, Demling R. Acute leukopenia during topical burn therapy with silver sulfadiazine. Am J Surg. 1978;135(6):818–819.

Landmark Article June 14, 1941: Sulfadiazine. Therapeutic Evaluation and Toxic Effects on Four Hundred and Forty-Six Patients. By Maxwell Finland, Elias Strauss, and Osler L. Peterson [Internet]. PubMed Labs. [cited 2017 Jul 2]. Available from: https://www.ncbi.nlm.nih.gov/labs/pubmed/6366263/?from_q=FINLAND+M%5Bauthor%5D

Stanford W, Rappole BW, Fox CL. Clinical experience with silver sulfadiazine, a new topical agent for control of pseudomonas infections in burns. J Trauma. 1969 May;9(5):377–88.

Eurenius K, Brouse RO. Granulocyte kinetics after thermal injury. Am J Clin Pathol. 1973;60(3):337–342.

Asko-Seljavaara S. Inhibition of bone marrow cell proliferation in burned mice. An in vitro study of the effect of fluid replacement and burn serum on bone marrow cell growth. Scand J Plast Reconstr Surg. 1974;8(3):192–7.

Thomson PD, Moore NP, Rice TL, Prasad JK. Leukopenia in acute thermal injury: evidence against topical silver sulfadiazine as the causative agent. J Burn Care Rehabil. 1989 Oct;10(5):418–20.


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