Primary Hyperparathyroidism: Still an Overtly Symptomatic Disease

Abstract

Introduction: Primary hyperparathyroidism (PHPT) is a    condition in which there is inappropriate increase in serum PTH in spite of increase in serum calcium. It is the            commonest cause of hypercalcemia in an outpatient setting. Though it is mostly asymptomatic at presentation in high income countries, it is still overtly symptomatic in our part of the world (1).

 Materials and Methods: A retrospective study of 46 patients who underwent surgery for PHPT from 1^st January 2014 to 31^st December 2014 was done and data was recorded and analysed.

 Observation and Results: A total of 46 patients diagnosed with PHPT underwent surgery during the mentioned          period. 26/46 were males and 20/46 were females. 26/46 (56.2%) presented before 5^th decade of life. The commonest organ system involved at presentation was renal followed by musculoskeletal systems. After biochemical confirmation and localisation imaging, 28/46 patients underwent focused          parathyroidectomy, 10/46 underwent full cervical exploration and 8/46 underwent combined surgery (due to concomitant thyroid pathology). The mean gland weight was 2.79 gm.

 Conclusion: In conclusion, in our study, the disease           presentation is overtly symptomatic and most often involving younger age group of patients. Renal system followed by musculoskeletal were commonly involved in our study.

 Keywords: PHPT- Primary hyperparathyroidism, focused parathyroidectomy