Impact of cold ischaemia time in deceased donor renal transplant – institutional experience

Abstract

Abstract

Introduction

 Kidney transplantation is the preferred treatment for patients requiring the renal replacement therapy, and kidneys from deceased donors are a major source for it. Deceased-donor kidney transplants is usually accompanied with the immediate renal ischemic injury due to cold ischemia time (CIT) that often results in reduced deceased-donor allograft function and survival. Prolonged CIT is also a considerable predictor of long-term graft loss. Cold ischemia time is an unchanged parameter over the years, which is relevant to the kidneys from deceased donors, can lead to higher rates of the chronic allograft loss.

Aim & objectives

 To evaluate the impact of cold ischaemia time on graft    function , graft survival and patient survival.

Materials and methods

            This was a retrospective and prospective study     conducted in the institute of

urology from 2004 to 2015.All the patients who underwent renal transplant from deceased donor were included in the study. Donor age , recipient age , cold ischaemia time, graft function , graft loss and patient survival data were collected.

Results

Mean age of the recipients was 36.6 years and that of donor was 34.4 years. Graft function was categorized as             IGF , DGF , PNF. Minimum CIT in our series was 100 min and the maximum CIT was 800 min. CIT was correlated with graft function. P value for CIT < 0.001 which is satistically        significant , CIT has got significant association in predicting graft function.