A comparative study of Tamsulosin, Nifedipine versus their combination in the management of Lower Ureteric Calculi

Balaji A.R, Chandramurali.R .

Abstract


 

Aim of study

In modern era treatment of lower ureteric stones has moved from open surgery to endoscopic and                non invasive methods. Medical expulsive therapy can be a viable option.This study focuses on managing ureteric      calculus with Nifedipine,Tamsulosin and combination of both the drugs and comparing the outcomes.

Method

58 symptomatic patients with lower ureteric       calculi of size < 10 mm were randomly assigned to treatment with Tamsulosin, Nifedipine and combination of both drugs (group 1 to 3).Each group was given Diclofenac (50 mg) on demand. Primary end point was rate of expulsion and      secondary end points were duration for stone expulsion,   analgesic usage, need for admission to hospital and forms of treatment.

Conclusion

 In the present study,onlyTamsulosin was found cost effective for lower ureteric stone expulsion therapy.Combination of both  Tamsulosin and Nifedipine provided no added advantage is not cost effective.

Keywords:Combination,Nifedipine,Tamsulosin,Ureteric          calculus.


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References


Beach MA, Mauro LS. (2006). Pharmacologic expulsive treatment of ureteral calculi. Ann Pharmacother, 40(7-8), 1361-8.

Hollingsworth JM, Rogers MA, Kaufman SR, Bradford TJ, Saint S, Wei JT, et al. (2006). Medical therapy to facilitate urinary stone passage: a meta-analysis. Lancet, 368, 1171-1179

Francesco Porpiglia. (2004). Nifedipine and Tamsulosin Both Effective Therapy for Lower Ureteral Stones. J Urol, 172, 568-571.

Liu M, Henderson SO. (2007). Myth: nephrolithiasis and medical expulsive therapy. CJEM, 9(6), 463-5.

Sterrett SP, Nakada SY. (2008). Medical expulsive therapy. SeminNephrol, 28(2), 192-9.


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