Amyloidosis with Urinary Tract involvement.
Abstract
Introduction
Amyloidosis is the extracellular tissue deposition of
fibrils - Low molecular weight subunits of a variety of normal
serum proteins. Amyloidosis involving the urinary tract is rare.
Materials and Methods
This is a single centre retrospective study of biopsy
proven amyloidosis affecting the urinary system (excluding
isolated renal amyloidosis) from January 2005 to August
2016. Clinical presentations, diagnosis and management
were studied and literature was reviewed.
Results
We identified a total of 7 patients, 6 (85.7%) male
and 1 (14.3%) female. Median age at presentation was 56
years. Primary and secondary amyloidosis were present in 2
and 3 patients respectively, it was unknown in 2 patients.
Two patients presented with haematuria and were detected
to have bladder lesions. Three patients had flank pain and
were diagnosed with ureteric strictures -they underwent balloon
dilatation and DJ stenting, two of them also had haematuria
along with bladder lesions. One patient was incidentally
detected to have a ureteric stricture causing hydroureteronephrosis
and a non-functioning kidney that was removed.
Bilateral antegrade DJ stenting was carried out in one patient
with a pelvic mass and obstructive uropathy, he was detected
to have light chain myeloma.
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PDFReferences
Sudhanshu Chitale, Mo Morsey, Danielle Peat, Ralph Webb.
Amyloidosis of Lower Genitourinary Tract: A Review. EAU-EBU
update series 5 (2007) 70–76.
Sipe JD, Cohen AS. Review: history of the amyloid fibril.
J Struct Biol 2000; 130 (2-3): 88-98.
Mark IR, Goodlad J, Lloyd-Davies RW. Localized amyloidosis
of the genito-urinary tract. J R Soc Med 1995;88:320-324.
Merrimen JL, Alkhudair WK, Gupta R. Localised amyloidosis
of the urinary tract: case series of nine patients. Urology
;67:904–9.
Livneh A, Shtrasburg S, Martin BM, Baniel J, Gal R, Pras M.
Light chain amyloidosis of the urinary bladder: A site restricted
deposition of an externally produced immunoglobulin. J Clin
Pathol 2001;54:920–3.
Tirzaman O, Wahner-Roedler DL, Malek RS, Sebo TJ, Li CY,
Kyle RA. Primary localized amyloidosis of the urinary bladder: a
case series of 31 patients. Mayo Clin Proc 2000;75:1264–8.
Nurmi MJ, Ekfors TO, Puntala PV. Secondary amyloidosis of
the bladder : a cause of massive haematuria. J Urol. 1987; 138
(1):44-5.
Murphy MN, Alguacil-Garcia A, MacDonald RG. Primary
amyloidosis of renal pelvis with duplicate collecting system.
Urology. 1986; 27(5):470-3.
Takahashi T, Miura H, Matsu-ura Y, Iwana S, Maruyama R,
Harada T. Urine cytology of localized primary amyloidosis of the
ureter: a case report. Acta Cytol 2005; 49:319–22.
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