Metabolic syndrome in preeclampsia - Analysis of insulin resistance and dyslipidemia.

Abstract

Preeclampsia is multi-factorial
in origin, despite extensive research the
etiology of preeclampsia remains unfolded.
Hence it is referred as disease of
the theories. Insulin resistance and
dyslipidemia may contribute to the onset
of preeclampsia. But available evidences
were controversial. Since we belong to
high risk ethnicity (south Indian) for insulin
resistance, we undertook this study
with a aim to analyse lipid profile and insulin
resistance (markers of metabolic
syndrome) in normotensive and preeclamptic
pregnant women. Biochemical
analysis was done in 50 normotensive
and 50 preeclamptic patients during their
third trimester. Preeclamptic women
were more insulin resistant ( p value less
than 0.05). They had significantly higher
triglyceride (p less than 0.0001) and LDL
cholesterol levels (p less than 0.012).
The HDL cholesterol in preeclamptic
group was significantly low. Pre pregnancy
BMI more than 25
was significantly associated with insulin resistance.
In preeclamptic group 46.2 percent
fulfilled the criteria for metabolic syndrome
as against only 15.4 percentages in
normotensive group. In conclusion preeclamptic
women were more insulin resistant
and having dyslipidemia to suggest
metabolic syndrome.