Cover Image

SCRUB TYPHUS IN NEONATES

VIJAYAN S

Abstract


Sepsis is one of the important cause of neonatal morbidity and mortality in a tertiary care hospital. Though most of these newborns will respond to appropriate antibiotics with good outcome few may not respond. Here we are going to discuss two newborns who presented with clinical features of sepsis, treated with higher antibiotics but not responded and where the alternative diagnosis had to be considered. As these babies had fever, hepatosplenomegaly with     thrombocytopenia and refractory shock, we thought of  unusual infections like leptospirosis, scrub typhus, dengue and empirically started on azithromycin. To our surprise their serology where found to be positive for scrub typhus and both these babies recovered well with azithromycin.


Full Text:

PDF

References


Oaks SC Jr, Ridgway RL, Shirai A, Twartz JC, 1983. Scrub Typhus. Bulletin No. 21. Kuala Lampur, Malaysia: Institute for Medical Research

Megan E Reller and J. Stephan dumler chapter 229 Nelson textbooks for PAEDIATRICS 20th edition page no.1504 to 1505.

Dumler JS, Siberry GK. Scrub Typhus (Orientia Tsutsugamushi). (Part XVI. Section 11. Chapter 226) In: Kliegman RM, Behrman Re, Jenson HB, Stanton BF, editors. Nelson Textbook of Pediatrics. 20th ed. Philadelphia: Saunders, Elsevier; 2007. pp. 1295–96

Raoult D. Orientia tsutsugamushi. In: Mandell GL, Bennett JE, Dolin R, editors. Principles and Practice of Infectious Diseases. 7th ed. Philadelphia: Churchill Livingstone; 2009. pp. 2529–30.

Indian J Anaesth. 2013 Mar-Apr; 57(2): 127–134. doi: 10.4103/0019-5049.111835 PMCID: PMC3696258 Amy G Rapsang and Prithwis Bhattacharyya

Dasch GA, Halle S, Bourgeosis AL. Sensitive microplate enzyme-linked immunosorbent assay for detection of antibodies against scrub typhus rickettsia, Rickettsia tsutsugamushi. J Clin Microbiol. 1979;9:38–48. [PMC free article] [PubMed]

Kim D, Yun NR, Yang TY, Lee JH, Yang JT, Shim S, et al. Usefulness of nested PCR for the diagnosis of scrub typhus in clinical practice: A prospective study. Am J Trop Med Hyg. 2006;75:542–5. [PubMed]

Manosroi J, Chutipongvivate S, Auwanit W, Manosroi A. Early diagnosis of scrub typhus in Thailand from clinical specimens by nested polymerase chain reaction. Southeast Asian J Trop Med Public Health. 2003;34:831–8. [PubMed]

Kim D, Kim SW, Choi SH, Yun NR. Clinical and laboratory findings associated with severe scrub typhus. BMC Infect Dis. 2010;10:108. [PMC free article] [PubMed]

Yi SY, Tae JH. Pancreatic abscess following scrub typhus associated with multiorgan failure. World J Gastroenterol. 2007;13:3523–5. [PMC free article] [PubMed]

Wang CL, Yang KD, Cheng SN, Chu ML. Neonatal scrub typhus: A case report. Pediatrics. 1992;89:965–8. [PubMed]

Mathai E, Rolain JM, Verghese L, Mathai M, Jasper P, Verghese G, et al. Case reports: Scrub typhus during pregnancy in India. Trans R Soc Trop Med Hyg. 2003;97:570–2. [PubMed]


Refbacks

  • There are currently no refbacks.


Creative Commons License
This work is licensed under a Creative Commons Attribution-NoDerivatives 4.0 International License.

An Initiative of The Tamil Nadu Dr MGR Medical University