LOCAL RESECTION OF AMPULLARY NEUROENDOCRINE TUMOR WITH HIGH RISK FACTOR (FACTOR VII DEFICIENCY)-case report
Abstract
ABSTRACT Ampullary neuroendocrine
tumors are extremely rare tumors with an
incidence of less than 0.3 of gastrointestinal
carcinoids and less than 2 of all tumors
of ampullary region. Ampullary neuroendocrine
tumors can present with
jaundice, or nonspecific abdominal discomfort
or gastrointestinal bleeding. Endoscopic
biopsy is done for histopathological
examination and to analyze
the tumor markers in the tissue like Chromogranin
A and Neuron specific
enolase.Pancreaticoduodenectomy is
often recommended as treatment of
choice for tumor of any size with no distant
spread.However ,less invasive procedures
like local excision and endoscopic
resection have also been successfully
attempted especially for ampullary
neuroendocrine tumor less than 2
cm size or in high risk surgical candidates.
Our patient had factor VII deficiency
and A Negative blood group.
Full Text:
PDFReferences
Lawrence B, Gustafson BI, Chan A, Veda
B, Kidd M, Maudlin IM (2011) the epidemiology
of gastroenteropancreatic
neuroendocrine Tumors. Endocrinol
Metab Clin North Am 40:1–18, vii
Rattner DW, Fernandez-del CC,
Brugge WR, Warshaw AL (1996)
Defining the criteria for local resection
of ampullary neoplasms.Arch
Surg 131:366–371.
Hartel M, Wente MN, Sido B,
Friess H, Buchler MW (2005)
Carcinoid of the ampulla of Vater. J
Gastroenterol Hepatol 20:676–681
Roggin KK, Yeh JJ, Ferrone CR,
Riedel E, Gerdes H, Klimstra DSet
al (2005) Limitations of ampullectomy
in the treatment of nonfamilial
ampullary neoplasms. Ann Surg
Oncol 12:971–980.
Kim J, Lee WJ, Lee SH, Lee KB,
Ryu JK, Kim YT et al (2011) Clinical
features of 20 patients with curatively
resected biliary Neuroendocrine
tumors. Dig Liver Dis 43:965–
Pitt SC, Pitt HA, Baker MS, Christians
K, Touzios JG, Kiely JM ET Al
(2009) Small pancreatic and periampullary
neuroendocrine Tumors:
resect or enucleate? J Gastrointest
Surg 13(9):1692–1698.
Paramythiotis D, Kleeff J, Wirtz M,
Friess H, Buchler MW (2004) Still
any role for Trans duodenal local
excision in tumors of the Papilla of
Vater? J Hepatobiliary Pancreat
Surg 11(4):239–244
Gilani, N. and Ramirez, F.C.
(2007) Endoscopic Resection of an
Ampullary Carcinoid Presenting with
Upper Gastrointestinal
Bleeding: A Case Report and Review
of the Literature. World Journal
of Gastroenterology, 13, 1268-1270.
Senda, E., Fujimoto, K., Ohnishi,
K., Higashida, A., Ashida, C., Okutani,
T., et al. (2009) Minute Ampullary
Carcinoid Tumor with Lymph
Node Metastases: A Case Report
and Review of Literature. World
Journal of Surgical Oncology, 7,
Hwang, S., Lee, S.G., Lee, Y.J.,
Han, D.J., Kim, S.C., Kwon, S.H., et
al. (2008) Radical Surgical Resection
for Carcinoid Tumors of the
Ampulla. Journal of Gastrointestinal
Surgery, 12, 713-717
Klimstra, D., Modlin, I.R.,
Coppola, D., Lloyd, R.V. and
Suster, S. (2010) the Pathologic
Classification of Neuroendocrine
Tumors: A Review of Nomenclature,
Grading and Staging Systems. Pancreas,
, 707-712
Refbacks
- There are currently no refbacks.
This work is licensed under a Creative Commons Attribution-NoDerivatives 4.0 International License.
An Initiative of The Tamil Nadu Dr MGR Medical University