University Journal of Pre and Paraclinical Sciences
NEUROENDOCRINE CARCINOMA OF STOMACH - A CASE REPORT
Abstract
Carcinoid tumors are neuroendocrine neoplasms
which are amine precursor uptake
decarboxylase(APUD)omas that arise from
enterochromaffin cells present throughout
the gut. The majority are found in the gastrointestinal
tract and more than 40 percent
occur in the small intestine. Gastric
carcinoids can be associated with endocrine
cell hyperplasia, chronic atrophic
gastritis, Zollinger-Ellison Syndrome(ZES).
These tumors secrete discrete bioactive
substances producing characteristic clinical
features and immunohistochemical patterns.
Neuroendocrine carcinoma are the
malignant counterpart of carcinoid tumor.
Here we report a case of neuroendocrine
carcinoma of stomach in a 40 year old female
presenting with recurrent vomiting,
pain abdomen and mass per abdomen.
Subtotal gastrectomy was done. Histopathological
examination revealed features of
Large cell neuroendocrine carcinoma
which showed positivity for Chromogranin
and Neuron specific enolase(NSE) immunohistochemically.
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