University Journal of Pre and Paraclinical Sciences
Association of serum uric acid level in Non Alcoholic Fatty Liver Disease.
Abstract
ABSTRACT Background Non-alcoholic
fatty liver disease (NAFLD) is a cause of
fatty liver, occurring when fat is deposited
(steatosis) in the liver not due to excessive
alcohol intake. NAFLD is considered a hepatic
manifestation of the metabolic syndrome.
Worldwide prevalence of nonalcoholic
fatty liver disease is 38percent.
Serum uric acid level has been suggested
to be associated with factors that
contribute to insulin resistance and metabolic
syndrome.Aim The aim of this study
is to investigate the association of serum
uric acid level and body mass index
(BMI) with non-alcoholic fatty liver disease.
Methods This observational study
was conducted in subjects who attended
the master health check up clinic of PSG
hospitals. 50 subjects with NAFLD and
50 non fatty liver subjects were included
in the study. NAFLD was diagnosed
based on the abdominal ultrasonographic
finding. Serum uric acid level and
body mass index (BMI) was also measured.
Uric acid quartiles were categorized
into four groups and
number of subjects who came under each
group was noted.Results The BMI was
compared between cases and controls.
The mean Body Mass Index (kgm) for
cases was 27.01 with SD 3.53 and for
controls was 23.91with SD 3.11. Elevated
BMI is associated with increased incidence
of NAFLD with a significant p value
of less than 0.05. The mean uric acid concentration
(mgdl) for cases is 5.73with SD
1.57 and for controls is 4.69with SD 0.91.
Increased serum uric acid concentration is
associated with increased incidence of
NAFLD with a significant p value of less
than 0.05.Conclusion This study showed
elevated BMI is associated with increased
incidence of NAFLD. Serum uric acid levels
are significantly associated with
NAFLD and high uric acid levels showed
high incidence of NAFLD compared to low
serum uric acid level.
Keyword :NAFLD,uric acid, body mass
index
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