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Mullerian Adenosarcoma of Uterus with Sarcomatous Overgrowth and Heterologous Component Associated with Stromal Deposit in Omentum

MALLIKA P .

Abstract


Mullerian adenosarcoma with sarcomatous           overgrowth (MASO) is a very rare variant of uterine sarcomas described by Clement as early as 1974. The presence of                 heterologous sarcomatous components is associated with             aggressive biological behavior. Case presentation. This is a case report of a 62-year female (P) presenting with                                          postmenopausal vaginal bleeding. Her preoperative USG              revealed subserosal broid with adherent omentum. She                underwent abdominal hysterectomy with bilateral oophorectomy. Histopathological diagnosis of resected specimen was Mullerian adenosarcoma with sarcomatousover growth and presence of heterologous elements involving body of the uterus. The whole thickness of the myometrium was involved along with the             presence of serosal nodules and omental deposits of                     sarcomatous component. Conclusion.MA is considered as a low-grade malignant tumor, but MASO is a high-grade tumor            frequently associated with invasion and metastasis with poor treatment outcome. Because of its rarity, correct identification of these tumors and distinction from other uterine sarcomas are a challenging job and hence its morphological features merits attention


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References


P. B. Clement and R. E. Scully, “Mullerian adenosarcoma of the uterus. A clinicopathologicanalysis of ten cases of a distinctive type of mullerian mixed tumor,” Cancer, vol. 34, no. 4, pp.1138–1149, 1974.

Y. Shi, Z. Liu, Z. Peng, H. Liu, K. Yang, and X. Yao, “The diagnosis and treatment of Mullerianadenosarcoma of the uterus,” Australian and New Zealand Journal of Obstetrics and Gynaecology,vol. 48, no. 6, pp. 596–600, 2008.

T. S. Patrelli, E. M. Silini, S. Gizzo et al., “Extragenital Mullerian adenosarcoma with pouch ofDouglas location,” BMC Cancer, vol. 11, article 171, 2011.

A. Gallardo and J. Prat, “Mullerian adenosarcoma: a clinicopathologic and immunohistochemicalstudy of 55 cases challenging the existence of adenobroma,” American Journal of Surgical Pathology, vol. 33, no. 2, pp. 278–288, 2009.

E.Recinos-Money,G.Escobar -Alfaro,J.Contreras,E.ZepedaCastilla, C. Parra-Torres, and P. DiCastro, “Ovarian adenosarcoma with elevated CA 125 antigen serum. A case report and literaturereview,” Cirugia y Cirujanos, vol. 76, no. 1, pp. 71–75, 2008.

M. Manoharan, M. A. N. Azmi, G. Soosay, T. Mould, and A. R. Weekes, “Mullerian adenosarcomaof uterine cervix: report of three cases and review of literature,” Gynecologic Oncology, vol.105, no. 1, pp. 256–260, 2007.

M. Niculescu, C. Simionescu, L. Novac, L. Mogoant and I.Mindrila, “Adenosarcoma of the uterinecervix: positive and differential diagnosis,” Romanian Journal of Morphology and Embryology, vol. 48,

no. 1, pp. 79–82, 2007.

H. H. Orenstein, R. M. Richart, and C. M. Fenoglio,“Mullerian adenosarcoma of the uterus: literature review,case report, and ultrastructural observations,” Ultrastructural Pathology, vol. 1, no. 2, pp. 189–200, 1980.

P. B. Clement, “Mullerian adenosarcomas of the uterus with sarcomatous overgrowth. A clinicopathological analysis of 10 cases,” American Journal of Surgical Pathology, vol. 13, no. 1, pp. 28–38, 1989.

R. Duggal, R. Nijhawan, N. Aggarwal, and P. Sikka, “Mullerian adenosarcoma (heterologous) of the cervix with sarcomatous overgrowth: a case report with review of literature,” Journal of Gynecologic Oncology, vol. 21, no. 2, pp. 125–128, 2010


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