Cover Image

A COMPARATIVE STUDY ON EFFICACY OF ANTITUBERCULOSIS DRUGS IN IMMUNOCOMPETENT AND IMMUNOCOMPROMISED SPUTUM POSITIVE PULMONARY TUBERCULOSIS PATIENTS.

SARAVANAKUMAR .

Abstract


ABSTRACT AIMS AND OBJECTIVES To compare the rate of sputum conversion in new smear positive pulmonary tuberculosis Immunocompetent and immunocompromised  patients. MATERIAL AND METHODS The study was conducted at RNTCP (Revised National Tuberculosis Control Programme) centre, Madurai Medical College and Rajaji Hospital, Madurai, Tamilnadu between January 2011 to June 2011.The study was a prospective study and consists of totally 100 patients of smear positive Pulmonary Tuberculosis(50 Immunocompetant patients and 50 Immunocompromised patients) (category- ) irrespective of age and sex. RESULTS AND OBSERVATION. In the present study, among immunocompetent patients, 42(84) patients            became smear negative at the end of the 2nd month, 48(96) patients became sputum smear negative at the end of 3rd month. Among immunocompromised patients, 45(90) patients became smear negative at the end of 2nd month,50(100)            patients became sputum smear negative at the end of 3rd month. SUMMARY CONCLUSION In the present study, sputum conversion at the end of third month was 96 in                          immunocompetant patients and 100 in immunocompromised patients. P 0.05, hence was not statistically significant. This study demonstrates that HIV seropositive status and DM are not a principal factor in delaying sputum conversion among patients receiving intensive phase tuberculosis treatment.


Full Text:

PDF

References


.Ravigilione MC,Snider DE Jr,Kochi A .Global epidemiology of tuberculosis: morbidity and mortality of a worldwide epidemic. JAMA 1995; 273:220-6

.Murray GDL. Styblo K. rouillon a. Tuberculosis in developing countries burden. I ntervention and cost. Bull Int Union Tuberc Lung Disc 1990:35;25-35.

Murray GDL. Styblo K. rouillon a. Tuberculosis in developing countries burden. I ntervention and cost. Bull Int Union Tuberc Lung Disc 1990:65:6-24.

Revised national tuberculosis control programme.(RNTCP) overview 2010.

Narain JP, Ying-Ru Lo:Epidemiology of HIV-TB in india in Asia.Indian J Med Res 120, October 2004;277-89.

Tuberculosis management, VK.Arora,Raksha Arora

Samar Banerjee and Mandira Banerjee :Diabetes and Tuberculosis Interface. Journal of Indian Medical Association Jyne 2005:103(6):318-22

Ponce A-De-leon, Ma DL Garcia-Garcia,MA C Garcia-Sancho,et al. Tuberculosis and Diabetes in Southern Mexico. Diabetes Cara 2004;27:1584-90

Ezung T ,Devi NT ,Singh TB. Pulmonary TB and DM –a study.J of IMA 2002;100;376.

Chittaranjan kal et al.Pulmonary TB and DM .Jour .Diab .Association of India, 1993;33(1);20

Surya Kirani KRL,Santher kumara V, Lakshmi Kumari R.coexistence of pulmonary TB and DM:some observation .Ind. J. Tub 1998,45:47-48.

Patel JC .Compilication in 8793 cases of D M, 14years study in Bombay Hospital, Bombay India. Ind J Med Sci 1989:43;177.

SHARMA ,Tuberculosis Management.

Toman `tuberculosis. WHO.Third edition.

www.ijmm.org/text.asp? 2010/28/1/21/58723. Indian J Med Microbiol[serial online] 2010 [cited 2011 oct 12];28:21-5

Park,social preventive medicine,20th edition

Arora VK, Singla N, Sarin R. Profile of geriatric patients under DOTS in Revised National Tuberculosis Control Programme. Indian J Chest Dis Allied Sci. 2003;45:231–235.

Concepcion F, Ang RMT, Myrna T, Mendoza MD. Tessa Tan Torres, MDAccuracy of AFB Smear Techniques at the

Health Center Level. Phil J Microbiol Infect Dis. 1997;26(4):153–155.

. Frimpong EH, Adukpo R, Owusu-Darko K. Evaluation of two novel Ziehl-Neelsen methods for tuberculosis diagnosis.

West Afr J Med. 2005 Oct–Dec;24(4):316–20.

Fujiki A, Giango C. & Endo S Quality control of sputum smears examination in Cebu Province. Int J Tuberc Lung Dis. 2002;6(1):39–46.

Gothi GD, et al. Ind. J. Tuberculosis. 1979;26(3):121.

Gopi PG, Chandrasekaran V, Subramani R, Santha T, Thomas A, Selvakumar N, Narayanan PR. Association of conversion & cure with initial smear grading among new smear positive pulmonary tuberculosis patients treated with

Category I regimen. J Med Res. 2006 Jun;123(6):807–14.

. Mathew P, Kuo YH, Vazirani B, Eng RH, Weinstein MP. Are three sputum acid-fast bacillus smears necessary for

discontinuing tuberculosis isolation? J Clin Microbiol. 2002 Sep;40(9):3482–4.

Dhingra VK, Nishi Aggarwal, Rajpal S, Aggarwal JK, Gaur SN. Validity and Reliability of Sputum Smear Examination as Diagnostic and Screening Test for Tuberculosis. Indian J Allergy Asthma Immunol. 2003;17(2):67–69.

. Warren JR, Bhattacharya M, De Almeida KN, Trakas K, Peterson LR. A minimum 5.0 ml of sputum improves the sensitivity of acidfast smear for Mycobacterium tuberculosis. Am J Respir Crit Care Med. 2000 May;161(15):1559–62.

Indian Journal of Medical Microbiology, (2010) 28(1): 21-5 Effectiveness of anti-tuberculosis treatment among patients

receiving highly active antiretroviral therapy at Vihiga District Hospital in 2007

Indian J Med Res 126, November 2007, pp 452-458. Sputum conversion at the end of intensive phase of category-I regimen in the treatment of pulmonary tuberculosis patients with diabetes mellitus or HIV infection.


Refbacks

  • There are currently no refbacks.


Creative Commons License
This work is licensed under a Creative Commons Attribution-NoDerivatives 4.0 International License.

An Initiative of The Tamil Nadu Dr M.G.R. Medical University