Cover Image




Diabetes mellitus is a major public health problem with increasing incidence worldwide and long term                  complications of various organs including lungs. These             complications are mainly a consequence of macro vascular and micro vascular damages of the target organs. The magnitude of the complications of this disease is related to its duration .The aim of this study is to compare PEFR and FEF 25-75 in                diabetics and control group,and its relation with duration of the disease. This case control study was carried out in the            Department of Physiology, Kilpauk Medical College, from June 2012 to October 2012 on 30 type 2 diabetic patients. For           comparison, 30 age and sex matched apparently healthy non diabetic subjects were also studied. Based on the duration of disease, diabetic patients were divided into A (5-10 years) and B (10-20 years). PEFR and FEF 25-75 of all the subjects were measured by an computerized spirometer (Super spiro). Data were analyzed by Student t-test, Ancova test and Mann-Whitney test. The mean percentage of predicted values of PEFR and FEF 25-75 values were significantly lower in patients with type 2 diabetes when compared to controls. PEFR decreases as           duration of diabetes increases, so it is inversely related to the duration of the disease. FEF 25-75 is not affected by the           duration of diabetes.

Full Text:



Bruce M. Koeppen, Bruce A . Stanton Berne & Levy Physiology- 6th Edition.

Nicki R. Colledge, Brian R. Walker, Stuart H. Ralston. Davidson’s Principles & Practice of Medicine -21 st edition.

Md Omar Ali , Shelina Begum , Noorzahan Begum , Taskina Ali , Sultana Ferdousi. PEFR and FEF25-75 in type 2 diabetes mellitus and their relationships with its duration J Bangladesh Soc Physiol. 2010 June; 5(1): 14-19

Shravya Keerthi G, Hari Krishna Bandi , Suresh M , Preetham J K , Mallikarjuna Reddy N , Sharan B Singh M Role of Duration of Diabetes on Ventilatory Capacities and Expiratory Flow Rates in Type 2 Diabetes Mellitus Journal of Biology, Agriculture and Healthcare , Vol 2, No.6, 2012

Andreoli & Carpenter’s Cecil Essentials of Medicine-8th edition

Gouher Banu S , Anita D, Pallavi K, Lata M, Manjunatha A. A comparative study of lung functions in type-2 diabetes and non diabetic subjects International Journal of Biomedical and Advance Research- 629

Sultan A. Meo , Abdul Majeed Al-Drees, Muhammad Arif, Khalid Al-Rubean, Lung function in type 2 Saudi diabetic patients, Saudi Med J 2006; Vol. 27 (3): 338-343

Kanya Kumari DH , Nataraj S M , Devaraj H S Correlation of duration of diabetes and pulmonary function tests in type 2 diabetes mellitus patients. Int J Biol Med Res. 2011; 2(4): 1168 -1170

Qasi Rais Ahmed, Sapna Goyal, Narendra Gupta ,Raj Bhadur Kamal,Shikky Garg. A comparative evaluation of pulmonary parameters in diabetes mellitus patients and non diabetes mellitus apparently healthy volunteer as control. Journal of pharmaceutical and scientific innovation.

Wendy A. Davis, Matthew Knuiman, Peter Kendall, Valerie Grange, Timothy M.E. Davis, Glycemic Exposure Is Associated With Reduced Pulmonary Function in Type 2 Diabetes. Diabetes

Care 27:752–757, 2004


  • There are currently no refbacks.

Creative Commons License
This work is licensed under a Creative Commons Attribution-NoDerivatives 4.0 International License.

An Initiative of The Tamil Nadu Dr M.G.R. Medical University