ADVERSE DRUG REACTION MONITORING OF METFORMIN IN A TERTIARY CARE HOSPITAL

Abstract

OBJECTIVE To study the incidence and
pattern of adverse effect of Metformin. To
assess the severity and outcome of adverse
effect of Metformin.METHODS This
study included 100 patients with diabetes
who are taking Metformin only. Patients
who were willing to participate in the study
were given a questionnaire containing
demographic data and adverse drug profile
of Metformin. The symptoms of adverse
drug reaction were documented.
They were also asked about any other
symptoms they had, apart from the questionnaire.
The causality assessment was
done by WHO assessment scale and severity
by using modified Hartwig seigel severity
assessment scale.RESULTS Our
study showed that most of the patients belong
to 41-50 years age group. Mostly they
were femalesand many were having disease
for less than a year. Most of the patients
developed adverse drugreaction.
Many patient had more than one adverse
drug reaction. The commonest adverse
reaction was hypoglycemia, gastritis, nausea,
bloating, loss
of appetite, myalgia, metallic taste followed
by dryness of tongue, vomiting,
loose stools and headache. The adverse
drug reactions (ADRs) mostly belongs to
possible category and were
mild.CONCLUSION Most of the patients
who were taking Metformin had atleast
one adverse drug reaction during the
treatment period. It is mild, needs dose
adjustment and life style modification.