ADVERSE DRUG REACTION PATTERN OF ANTI-ASTHMATIC DRUGS PRESCRIBED IN ASTHMA OUT-PATIENT DEPARTMENT IN A TERTIARY CARE HOSPITAL

Abstract

PATTERN AND SEVERITY OF ADVERSE
DRUG REACTION OF ANTI-ASTHMATIC
DRUGS PRESCRIBED IN MEDICINE
OUTPATIENT DEPARTMENT IN A TERTIARY
CARE HOSPITAL OBJECTIVE To
study the pattern and severity of adverse
drug reactions of anti-asthmatic drugs in
patients attending Medicine out- patient
department in a tertiary care hospital.
METHODOLOGY The study was conducted
in adult patients with Bronchial
Asthma attending Asthma outpatient of a
tertiary care hospital between August 2013
to October 2013. Study period was 3
months. Sample size was 500. After getting
approval from the Institutional Human
ethics committee, 794 prescriptions were
screened, 500 prescriptions that met the
inclusion criteria were chosen for analysis.
Adverse Drug Reactions (ADR) were
documented in WHO ADR reporting form.
Causality assessment of the ADR was
done by WHO causality assessment scale.
Severity was assessed using
Modified Hartwig Siegel severity assessment
scale.RESULTS Most of the patients
were in the age group of 61-70 years.
Males constituted 34 percentage and females
66 percentage. Beta 2 agonists
were the most commonly prescribed antiasthmatic
drug group. Adverse Drug Reactions
were more common in elderly females.
Tremor was the most common Adverse
Drug Reaction encountered. Most
of the ADR comes under possible category
of WHO causality assessment scale
and were mild.CONCLUSION Beta 2 agonists
were the most commonly prescribed
anti asthmatic drug group. 34 percentage
of patients encountered Adverse Drug Reactions.
Adverse Drug Reactions were
more common in elderly females. Tremor
was the most common Adverse Drug Reaction
encountered. Most of ADRs were
mild and comes under possible category
of WHO causality assessment scale.