ADVERSE DRUG REACTION PATTERN OF ANTI PSYCHOTIC DRUGS PRESCRIBED IN PSYCHIATRY OUT-PATIENT DEPARTMENT IN A TERTIARY CARE HOSPITAL

Abstract

OBJECTIVE-To study the pattern of adverse
drug reactions of Anti psychotic
drugs in patients attending the Psychiatry
out- patient department at Rajiv Gandhi
Government General Hospital
.METHODOLOGY-400 patients attending
psychiatry OPD were enrolled in the
study. Duration of study was 2 months.
Adverse drug reactions of Anti psychotic
drugs were documented. Causality assessment
of ADRs was done using WHO
Causality assessment scale. Severity assessment
was done using Modified Hartwig
Siegel severity assessment
scale.RESULTS-Most of the patients were
in the age group of 31- 40 years. Males
constituted 60 percentage and females 40
percentage of test population. Risperidone
was the most commonly prescribed Anti
psychotic drug. Among 400 patients, 236
patients developed adverse drug reaction .
Sedation was the most common adverse
drug reactions encountered with all the
three drugs. Extrapyramidal symptoms
(Tremors , Dystonia) were more
common with Haloperidol and Chlorpromazine
whereas weight gain was seen
only with Risperidone. 53 percentage of
ADRs come under probable category of
WHO Causality assessment scale.95 percentage
of ADRs fall under mild category
o f s e v e r i t y a s s e s s m e n t
scale .CONCLUSION- Risperidone was
the most commonly prescribed Anti psychotic
drug. Sedation was the most common
adverse drug reaction encountered.
Most of the ADRs were mild and
comes under Probable category of WHO
causality assessment scale.