University Journal of Pre and Paraclinical Sciences
ALK POSITIVE PRIMARY EXTRANODAL ANAPLASTIC LARGE CELL LYM PHOMAMASQUERADING AS A SOFT TISSUE SARCOMA A CASE REPORT
Abstract
Anaplastic Large Cell Lymphoma (ALCL)
is a rare type of T-cell null cell Non Hodgkin
Lymphoma. It is seen predominantly in
children and young adults. Some of these
tumors express an enzyme called
Anaplastic Lymphoma Kinase (ALK) produced
by the alk gene, an oncogene. The
disease can present purely nodally or with
extranodal involvement. Extranodal involvement
can mimic a soft tissue sarcoma.
Purely extranodal presentation is
very rare and most of these are ALK-ve
ALCL than ALKpositive ALCL. We present
a case of a primary extranodal ALK positive
Anaplastic Large Cell Lymphoma that
presented clinically as a soft tissue sarcoma
in a 56-year-old female.
Full Text:
PDFReferences
Stein H, Mason DY, Gerdes J, et al.
The expression of the Hodgkin’s disease
associated antigen Ki-1 in reactive and
neoplastic lymphoid tissue: evidence that
Reed-Sternberg cells and histiocytic malignancies
are derived from activated
lymphoid cells. Blood. 1985; 66:848-858.
Swerdlow S.H.Campo E., Harris N.L.,
Jaffe E.S., Pileri S.A., Stein H., Thiele J.,
Vardiman J.W. (Eds.): WHO Classification
of Tumours of Haematopoietic and
Lymphoid Tissues. IARC: Lyon 2008.
Rekhi B, Sridhar E, Viswanathan
S et al. ALK+ anaplastic large cell
lymphoma with cohesive, perivascular
arrangements on cytology, mimicking
a soft tissue sarcoma: a report
of 2 cases. Acta cytol. 2010 Jan-
Feb;54(1):75-8.
Kerry J. Savage, Nancy Lee Harris,
Julie M. Vose, et al. ALKve
anaplastic large-cell lymphoma is
clinically and immunophenotypically
different from both ALK+ ALCL and
peripheral T-cell lymphoma, not otherwise
specified: report from the International
Peripheral T-Cell Lymphoma
Project. Blood, 2008 111:
-5504.
Eric Jacobsen. Anaplastic Large -
Cell Lymphoma, T-/ Null- Cell Type.
The Oncologist 2006 ; 11:831-840.
Emilio M. Pereira, Sueli A. Maeda
and Jorge s. Reis -Filho. Sarcomatoid
Variant of Anaplastic Large Cell
Lymphoma Mimicking a Primary
Breast Cancer. Arch Pathol lab med
– vol 126, 6, June 2002.
Komal Galani, Suryakanth R. Gurudu,
Longwen Chen et al. Anaplastic
Large Cell Lymphoma, ALK–
Negative Presenting In the Rectum:
A Case Report And Review of The
Literature. Open Journal of Pathology,
, 3, 37-40.
Refbacks
- There are currently no refbacks.
This work is licensed under a Creative Commons Attribution-NoDerivatives 4.0 International License.
An Initiative of The Tamil Nadu Dr M.G.R. Medical University