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AN ANALYSIS OF THE LEVELS OF SERUM SODIUM AND POTASSIUM IONS IN SENILE CATARACT PATIENTS

PRIYA DARSINI R RAJAKRISHNAN

Abstract


Back ground Senile cataract is one of the
consequences of ageing. With ageing the
alteration in membrane permeability of the
lens epithelium coupled with the changes
in sodium and potassium ion levels in
aqueous humour may accentuate ionic imbalance
within the lens and progression of
cataract.Aim To compare serum sodium
and potassium ion levels in senile cataract
patients with that of normal individuals.
Materials and methods 50 males with senile
cataract were randomly selected from
the outpatient facility of department of ophthalmology,
Government Rajaji Hospital,
Madurai. 50 age matched males without
senile cataract were taken as controls.
Both cases and controls were on normal,
mixed, south Indian diet. Individuals with
secondary cataract, hypertension or diabetes,
individuals on medications and disorders
affecting serum sodium or potassium
ion levels, dehydration, edema or on salt
restricted diet were excluded from the
study. After getting written informed consent,
basal parameters were measured.
Ophthalmic evaluation of all participants
was done. Under strict aseptic precautions
2 ml of venous blood was collected
and levels of serum sodium and potassium
ions were estimated by auto analyzer
Easylyte method.Results The data
obtained was analyzed using Students t
test. Serum levels of sodium ions were
found to be higher in cases 142mEq per l
than in controls 139.5mEq per l with a significance
of less than 0.001. There was no
significant difference in the serum levels
of potassium ions in cases 4.192mEq per
l compared to controls 4.136mEq per
l.Conclusion An elevated level of serum
sodium ions may be a risk factor for progression
of senile cataract.


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References


Barber CW. Free amino acids in senile

cataractous lenses: possible osmotic

etiology. Investigative Ophthalmology.

; 7: 564–567.

Bunce GE, Kinoshita J, Horwitz J.

Nutritional factors in cataract. Annual

Review of Nutrition.1990; 10:233–54.

Clayton RM, Cuthbert J, Phillips CI,

Bartholomew RS, Stokoe NL, Fytch T

et al. Analysis of individual cataract

patients and their lenses: A progress

report. Experimental Eye Research.

; 31:533–536.

Clayton RM et al. Some risk factors

associated with cataract in Scotland:

A pilot study. Trans Ophthalmology

Society. 1982; 102: 331–32.

Daliles MB, Kinsohita JH. Pathogenesis

of cataract. Duane’s Foundations

of Clinical Ophthalmology.

Lippincott-Raven Publishers.

; 2–5.

Delamere NA, Paterson CA. Crystalline

lens. Duane's Foundations of

Clinical Ophthalmology. Lippincott-

Raven Publishers.2001; 5–11.

Donnelly CA, Seth J. et al. Some

blood plasma constituents correlate

with human cataract. British Journal

of Ophthalmology.1995; 79: 1036–

Kuszak JR. Embryology and anatomy

of the lens. Duane's Clinical

Ophthalmology. Lippincott - Raven

publishers. 2000; 2–8.

Gandolfi SA, Tomba MC, Maraini

G. 86-Rb efflux in normal cataractous

human lenses. Curr Eye Res.1985;

: 753-758.

Harrisons textbook of internal

medicine.17th Edition.

Leske MC, Chylack LT, Wus Y.

The lens opacities case-control

study. Archives of Ophthalmology.

; 109.

Lucas VA, Duncan G, Davies P.

Membrane permeability characteristics of

perfused human senile cataractous

lenses. Exp Eye Res. 1986; 42: 151–

Luntz MH. Clinical types of cataract.

Duane's Clini cal Ophthalmol -

ogy. Lippincott-Raven publishers. 2000;

–7.

Maraini G, Pasino M. Active and passive

rubidium influx in normal human

lenses and in senile cataracts. Exp Eye

Res. 1983; 36: 543–549.

Minassian DC, Mehra V. Blinded by

cataract: Each year projection from the

first epidemiological study of incidence of

cataract blindness in India. British Journal

of Ophthalmology. 1990; 74:341–343.

Mirsamadi M, Nourmohammadi I,

Imamian M. Comparative study of serum

Na+ and K+ levels in senile cataract

patients and normal individuals. Int J

Med Sci 2004;1:165-9.

Nourmohammadi I, Gohari L, Modarres

M, Ghayoumi A. Evaluation of erythrocyte

glutathione peroxidase, superoxide

dismutase and total antioxidants in

cataract patients. Archives of Iranian

Medicine. 2001; 4:123–127.

Phillips CI, Bartholomew RS, Clayton

R, Duffy J, et al. Cataract: A search

for associations or causative factors. Excerpta

Medica. 1980; 19–25.

Raven J. Physiology of the

lens. Duane's Clinical Ophthalmology.

Lippincott-RavenPublisher.2001; 2–9.

Shoenfeld ER et al., Italian-

American Cataract Study. Recent

epidemiologic studies on nutritionand

cataract in India, Italy and

the United StatesJournal of Americ

a n C o l l e g e o f N u t r i -

tion. 1993;12:521–6.

Sperduto RD, Hiller R. The

prevalence of nuclear, cortical and

posterior sub-capsular lensopacities

in a general population sample.

D u a n e ' s C l i n i -

cal Ophthalmology. 1984; 91:815–

Sperduto RD. Epidemiological

aspects of age related cataract.

Duane's Clinical Ophthalmology.

Lippincott-Raven publishers.

; 12–14.

The Italian-American Cataract

Study Group. Risk factors for agerelated

cortical, nuclear andposterior

sub capsular cataracts. American

Journal of Epidemiology. 1991;

:541–44.

Van Heyningaen R. The Lens:

Metabolism and cataract. The Eye

Academic Press, 1961:380-

West SK, Valmadrid CT. Epidemiology

of risk factors for age related

c a t a r a c t . S u r v e y o f

Ophthalmology.1995; 39:323-327.


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