University Journal of Pre and Paraclinical Sciences
Serum Leptin Levels In Infertile Males.
Abstract
Background.The incidence of obesity is on
the rise and infertility among men is also
agrowing problem in the recent years.
Leptin, an adipocyte derived protein hormone,
has emerged asa metabolic link between
nutrition and fertility by its involvement
in regulation of reproductive functionin
both experimental animals and humans.
Several studies support the role of
serum leptin in theregulation of gonadal
functions in men indirectly via the central
neuroendocrine system and directlyvia peripheral
tissue membrane receptors. Establishment
of such a link may provide a
new insightinto the causes of infertility and
may lead to better treatment modalities in
infertile men. In this study
we aim to compare the serum leptin levels
among a group of normospermic and oligospermic
menand correlate leptin levels
with Body Mass Index(BMI). Materials and
Methods.A cross sectional casecontrol
study was conducted among 60 men at
the age group of 25 to 40 years attending
an infertilityclinic. 30 men diagnosed as
oligospermic as per WHO criteria (less
than 15 million sperm per ml,consistent
with the 5th percentile for fertile men)
were grouped as cases.30 men withnormospermiawere
selected as controls.The
height,weight and BMI was calculated. 5
ml of blood was collected andserum leptin
levels were analysed using the leptin
ELISA kit. The data obtained was analysed
using SPSS software version 7.5.
Independent student t test was employed.
p value less than 0.05 was taken
as significant.Results.Oligospermic males
had a significantly higher BMI than that of
the controls. The mean serum leptin levels
of the oligospermic males was found to be
significantly higher Than that of the controls.
A strong positive correlation was observed
between the BMI and leptin
l e v e l s of both th e s t u d
groups.Conclusion.Increased BMI and serum
leptin levels in oligospermic
males suggest that obesity is associated
with infertility in men and a possible link
between the
adipocyte derived hormone, leptin and male
gonadal dysfunction.
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