University Journal of Pre and Paraclinical Sciences
DETERMINATION OF VANCOMYCIN MINIMUM INHIBITORY CONCENTRATION AMONG STAPHYLOCOCCUS AUREUS ISOLATES
Abstract
Resistance and decreased susceptibility to
Vancomycin among Staphylococcus
aureus is on the rise. Therefore it is important
to screen Staphylococcus aureus isolates
for Vancomycin sensitivity to categorize
them as vancomycin susceptible, vancomycin
intermediate-susceptible (VISA)
and vancomycin resistant (VRSA), so as to
curb their spread in hospital settings. The
determination of MIC of vancomycin
among susceptible isolates is required to
administer the drug in the minimum required
dosage. Over a period of 2 months,
vancomycin MIC of all the S. aureus isolated
in the Institute-laboratory was determined
by agar dilution method and Hi-
Comb method. All 50 isolates were found
to be sensitive to vancomycin. Agar dilution
method was found to be a better
method for vancomycin MIC determination.
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