University Journal of Pre and Paraclinical Sciences
PSEUDO-GAUCHER CELLS IN DISSEMINATED ATYPICAL MYCOBACTERIAL INFECTION - A CASE REPORT
Abstract
Atypical Mycobacteria also known variably
as Mycobacteria other than tubercle
(MOTT),Non Tuberculous Mycobacteria
(NTM) and Environmental Mycobacteria
(EM)(1) are ubiquitous in theenvironment
existing in soil and water, as pathogens in
birds and cattle and as pharyngeal flora
inclinically well humans(2). Only rarely described
as an invasive pathogen in immunocompetenthumans,
they frequently
cause disseminated disease in patients
with primary and acquired immunedeficiency
syndrome. One such case is presented
here. A 19 year old female presented
withgeneralized lymphadenopathy,
organomegaly and opportunistic infections.
She was treated in thepast 5 times as a
case of tuberculosis. She had normal
plasma glucose and she tested negative
forHIV ELISA. Histopathological examination
of the lymph node received showed
sheets of Pseudo-Gaucher cells. Sections
stained by Ziehl-Neelsen showed acid fast
bacilli loaded within thehistiocytes (Pseudo
-Gaucher cells).
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PDFReferences
John M Grange and Alimuddin I.
Zumla. Human disease due to Environmental
Bacteria and Nocardia. Page
, Manson’s Tropical Diseases.
nd ed.2 Surendran Thavagnanam et al., Atypical
Mycobacterial Infections in children: the case
for early diagnosis. The Ulster Medical Journal
(3): 192-194 september 2006
Chapter 167:Non Tuberculous Mycobacterial
Infections. Harrison’s principles of Intestinal
Medicine 18th ed.
John M Grange and Alimuddin I. Zumla. Human
disease due to Environmental Bacteria
and Nocardia. Page 1040, Manson’s Tropical
Diseases. 22nd ed.
John M Grange and Alimuddin I. Zmla. Human
disease due to Environmental Bacteria
and Nocardia. Page 1041, Manson’s Tropical
Diseases. 22nd ed.
John M Grange and Alimuddin I. Zumla. Human
disease due to Environmental Bacteria
and Nocardia. Page 1046, Manson’s Tropical
Diseases. 22nd ed.
Clark B. Inderlied et al., The Mycobacterium
Avium Complex. Clinical Microbiology Reviews,
July 1993 Vol 6 No. 3., Page 266-310
Non Tuberculous Mycobacterial Lymphadenitis.
Ioachim’s Lymph node Pathology 4th ed.
P Dunn, M-C Kuo, C-F Sun. Pseudo-
Gaucher Cells in mycobacterial infection: a
report of 2 cases.Journal of clinical pathology
;58:1113-1114 doi: 1136/ JCP.
018176.
Diseases of the Immune System. Robbins
and Cotran Pathologic Basis Of Disease. 8th
ed.
The Central Nervous System: Tuberculosis.
Page 1301. Robbins and Cotran Pathologic
Basis Of Disease. 8th ed.
Mononuclear phagocytes:
Page264. Wintrobe’s Clinical Hematology
th ed.
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