University Journal of Pre and Paraclinical Sciences
SERUM FERRITIN IN ATHEROSCLEROTIC PERIPHERAL VASCULAR DISEASE VEENA JULIETTE AMALADOSS
Abstract
Background- Iron is a trace element
essential for the body because it is an important
constituent of haemoglobin which is a carrier of
oxygen in the body. Iron has also been found to
cause harmful effects when it is found in excess
since it increases the production of free radicals
which produce oxidized LDL and lipid peroxides
involved in the pathogenesis of atherosclerosis,
which is a chronic inflammatory disease.
Peripheral vascular disease (PVD) is a prototype
of chronic systemic atherosclerosis characterized
by stenoses and occlusions in the peripheral
arterial bed of lower limbs. A number of
researches have been undertaken to determine
the association between the status of body iron
and coronary atherosclerosis. But there is little
consensus about the causal relationship in the
studies conducted so far.The objective of this
study was to find out the Iron status in
atherosclerotic peripheral vascular disease by
measuring serum ferritin in patients attending our
hospital. This could serve as a representative of
the south Indian population. Methods- This
case-control study was conducted in the
department of Vascular surgery in Rajiv Gandhi
Government General Hospital, Chennai. 50
patients of atherosclerotic peripheral vascular
disease, defined by Ankle Brachial Pressure
Index 0.9 were included in the study. The
controls were 50 healthy subjects matched for
age and sex recruited. Serum Ferritin was
measured using Immunoturbidimetry. The
reference values are 20-250 g per L for men and
20-200 g per L for women. Results- The mean
serum ferritin level in cases and controls were
203.3 g per L and 180.5 g per L, respectively.
Student t test was used to calculate statistical
significance and no significant difference was
found in ferritin levels between cases and
controls. Conclusion- Serum ferritin is not a
significant risk factor for atherosclerotic
peripheral vascular disease in the study
population.
Full Text:
PDFReferences
G Premalatha, S Shanthirani, R Deepa, J
Markovitz and V Mohan; Prevalence and risk
factors of peripheral vascular disease in a
selected south Indian population: The Chennai
based Urban population study; Diabetes Care;
; 23; 1295-1300
Gary M. Britterham; Disorders of Iron
metabolism: Iron deficiency and overload;
Haematology; Basic Principles and Practice; 2
nd
edition; Ch 38; 492-576
Yuan XM, Brunk UT. Iron and LDL-oxidation in
atherogenesis. APMIS 1998; 106: 825–42.
Horwitz L, Rosenthal E. Iron-mediated
cardiovascular injury. Vasc Med 1999; 4: 93–99
Chau L. Iron and atherosclerosis. Proceedings
of the National Science Council, Republic of
China – Part B. Life Sci 2000; 24: 151–55.
Meyers DG. The iron hypothesis: does iron
play a role in atherosclerosis? Transfusion 2000;
: 1023–29.
Gackowski D, Kruszewski M, Jawien A,
Ciecierski M, Olinski R. Further evidence that
oxidative stress may be a risk factor responsible
for the development of atherosclerosis. Free
Radic Biol Med 2001;31: 542–47.
Rice-Evans C, Burdon R. Free radical–lipid
interactions and their pathological
consequences. Prog Lipid Res 1993; 32:
–110.
Halliwell B, Gutteridge J. Role of free radicals
and catalytic metal ions in human disease: an
overview. In: Packer L, Glazer A (eds).Methods
in enzymology, vol. 186. San Diego: Academic
Press, 1990:1–85.
Lamb D, Leake D. Iron released from
transferring at acidic pH can catalyse the
oxidation of low density lipoprotein.FEBS Lett
; 352:15–18.
Leake D, Rankin S. The oxidative modi.
cation of low-density lipoproteins by
macrophages. Biochem J 1990; 270: 741–48.
Steinbrecher U, Zhang H, Lougheed M. Role
of oxidatively modi. Ed LDL in atherosclerosis.
Free Radic Biol Med 1990; 9: 155–68.
Steinberg D, Pathasarathy S, Carew T, Khoo
J, Witzum J. Beyond cholesterol: modi. cations of
low-density lipoprotein that increase its
atherogenecity. N Engl J Med 1989; 320:
–24
De Valk B, Marx J. Iron, atherosclerosis, and
ischemic heart disease. Arch Intern Med 1999;
: 1542–48.
Eif DW, Simmons RD. Nitric oxide mediates
iron release from ferritin. Arch Biochem Biophys
; 283: 537–41.
Ambrosio G, Tritto I, Golino P. Reactive
oxygen metabolites and arterial thrombosis.
Cardiovasc Res 1997; 34: 445–52.
Pratico D, Pasin M, Barry OP et al.
Iron-dependent human platelet activation and
hydroxyl radical formation: involvement of protein
kinase C. Circulation 1999; 99: 3118–24.
Virgil F. Fairbanks M.D. et al. Iron
metabolism; Tietz textbook of clinical chemistry;
rd
ed, Ch 46; 1698-1704
David A. Lipschitz et al; A clinical evaluation
of serum Ferritin as an Index of Iron stores;
NEJM; 1974; Vol 290; 1213-1216
Haidari M, Javadi E, Sanati A, Hajilooi M,
Ghanbili J. Association of increased ferritin with
premature coronary stenosis in men. Clin Chem
; 47: 1666–72.
Say AE, Gursurer M, Yazicioglu MV, Ersek B.
Impact of body iron status on myocardial
perfusion, left ventricular function, and
angiographic morphologic features in patients
with hypercholesterolemia. Am Heart J 2002;
: 257–64.
Salonen JT, Nyyssonen K, Korpela H,
Tuomilehto J, Seppanen R, Salonen R. High
stored iron levels are associated with excess risk
of myocardial infarction in eastern Finnish men.
Circulation 1992; 86: 803–11.
Salonen JT, Nyyssonen K, Salonen R. Body
iron stores and the risk of coronary heart
disease. N Engl J Med 1994; 331: 1159;
discussion 1160.
Manttari M,Manninen V, Huttunen JK et al.
Serum ferritin and ceruloplasmin as coronary risk
factors. Eur Heart J 1994; 15: 1599–603.
Stampfer MJ, Grodstein F, Rosenberg I,
Willett WC, Hennekens CH. A prospective study
of plasma ferritin and risk of myocardial infarction
in US physicians. Circulation 1993; 87: 688
Danesh J, Appleby P: Coronary heart disease
and iron status: meta-analyses of prospective
studies. Circulation 1999, 99:852-854.
Moore M, Folsom AR, Barnes RW, Eckfeldt
JH: No association between serum ferritin and
asymptomatic carotid atherosclerosis. The
Atherosclerosis Risk in Communities (ARIC)
Study. Am J Epidemiol 1995, 141:719-723.
Zacharski LR, Chow BK, Howes PS,
Shamayeva G, Baron JA, Dalman RL, et al.:
Reduction of iron stores and cardiovascular
outcomes in patients with peripheral arterial
disease: a randomized controlled trial. JAMA
, 297:603-610.
Cook JD. Defining optimal body iron. Proc
Nutr Soc 1999; 58: 489–95.
Cook JD. The measurement of serum
transferrin receptor. Am J Med Sci 1999; 318:
–76.
Refbacks
- There are currently no refbacks.
This work is licensed under a Creative Commons Attribution-NoDerivatives 4.0 International License.
An Initiative of The Tamil Nadu Dr M.G.R. Medical University