University Journal of Pre and Paraclinical Sciences
THE EFFECTS OF CIGARETTE SMOKING ON GLYCOSYLATED HEMOGLOBIN (HbA1C) IN NON-DIABETIC INDIVIDUALS
Abstract
Abstract : Background Cigarette smoking
is associated with an increased risk of
Type 2 diabetes mellitus. Cigarette smoking
is known to cause a transient elevation
in blood glucose concentration. Glycosylated
hemoglobin (HbA1c) is a marker of
long-term glucose homeostasis reflecting
an average blood glucose concentration in
past 2-3 months. The effect of cigarette
smoking on average blood glucose levels
as measured by glycosylated hemoglobin
have yet received little attention. Aim and
Objective This study was done to assess
the effect of smoking on blood glucose
concentration by comparing glycosylated
hemoglobin (HbA1c) between non-diabetic
c igarette smokers and nonsmokers.
Materials and Methods This is a
cross sectional case control study involving
60 participants. Of them case group
consists of 30 non-obese, non-diabetic
males of age group between 20-40 years
who smoke 10 filter cigarettes per day or
more for not less than 5 years. 30 healthy
age matched non-obese males who do not
smoke cigarette were recruited for control
group.
After an overnight fast of 12 hours the serum
glucose concentration and the glycosylated
hemoglobin levels were estimated
in all subjects and the values were compared
between the cases and control using
students t test.Results There is no significant
increase in the fasting serum glucose
levels between the cases100.212.37
and the controls 103.19.64. There is a significant
increase in the glycosylated hemoglobin
level in smokers 5.480.83 when
compared with the non-smokers 4.560.34
with p-value 0.001.Conclusion The results
from the present study suggest that the
level of glycosylated hemoglobin is increased
in the non-diabetic smokers when
compared to the non-smokers.
Keyword :Key wordsCigarette smokers,
non-smokers, non-diabetic, glycosylated
hemoglobin.
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