ANTIMICROBIAL SENSITIVITY PATTERN OF E.COLI IN URINARY TRACT INFECTION- A RETROSPECTIVE ANALYSIS
Abstract
Aim- To determine the current trends in
antibiotic susceptibility pattern of E. coli at
a tertiary care hospital in, in- patients with
urinary tract infections. Materials and
methods- A retrospective analysis was
done in Tirunelveli Medical College Hospital
on 3581 urine culture reports issued for
suspected urinary infections in, inpatients
of the hospital during a 6months period.
The common microorganisms causing urinary
tract infections and microbial drug
sensitivity pattern were analyzed on 578
samples which were found to be culture
positive. Results- The common uropathogen
identified was E.coli (38.2). The frequency
of urinary infections in percentage
was more in the age groups 0-9years
(10.2) 50-59years (9.6) in males whereas
in females it was more in the age group of
20-29(14.8). The aminoglycoside antibiotic
amikacin showed the highest sensitivity
(94.19) towards E.coli and cotrimoxazole
showed the least sensitivity
(15.9).Conclusion- E.coli is the predominant
uropathogen identified in our hospital,
showing the highest
sensitivity to the amino glycoside, amikacin
and the least sensitivity to cotrimoxazole.
Keyword :UTI, E.coli, amikacin, cotrimoxazole
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PDFReferences
Betty A. Forbes, Daniel F SAHM, Alice
S. Weissfeld, Bailey and Scott’s
Diagnostic Microbiology, 11th edition,
chapter 60,927.
Rushton H.G : urinary tract infection
in children. Epidemiology, Evaluation
and Management, Paediatr.
Clin.North Am. 1997, 44.1133-114.
Kasper Braunwald Fauci Hausen
Longo Jameson, Harrison’s principles
of internal medicine, Walter E
Stamm ,Urinary tract infections,17th
edition,1825.
Siddharth N shah, API text book of
Medicine, R. Kasi visweswaran urinary
tract infection8th edition,760.
New HC. Urinary tract infections.
Am J Med 1996; 100 (Suppl.4A): S63-
Jones RN, Impact of changing
pathogens and antimicrobial susceptibility
pattern in treatment of serious
infections in hospitalized patients. Am
J Med. 1996; 100 (Suppl.6A): S3-12
Yilmaz K, Nilay C, Ayesegul G, et al,
Cotrimoxazole and Quinolone resistance
in E.coli isolated from UTI over
the last ten years. Int. J of Antimicrobial
agent 2005; 26(1); 75-77.
Manjunath GN , Prakash R , Vamseedhar
Annam , Kiran
Shetty,Changing trends in the spectrum
of antimicrobial drug resistance
pattern of uropathogens isolated from
hospitals and community patients with
urinary tract infections in Tumkur and
Bangalore Int J Biol Med Res. 2011; 2
(2): 504 –507
K.R. Rajesh, S. Mathavi, R.Indra Priyadarsini,
Prevalence of Antimicrobial Resistance
in Uropathogens and determining
Empirical Therapy for Urinary Tract Infections,
IJBMS 2011;2(4)
Joshi M C et al. Study of Antibiotic
Sensitivity Pattern In Urinary Tract Infection
At A Tertiary Hospital NJIRM 2011; 2
(3): 43-46
Asad U Khan and Mohd S Zaman,
Multiple drug resistance pattern in Urinary
Tract Infection patients in Aligarh
,Biomedical Research 2006; 17 (3):
-181
Sohely Sharmin, Farhana Alamgir,
Fahmida, Ahmed Abu Saleh. Antimicrobial
sensitivity pattern of uropathogens in children.
Bangladesh J Med Microbiol 2009;
(01): 18-22
Chakupurakal R,Ahmed M, Sobithadevi
DN,Chinnapan S,Reynolds T,
Urinary tract pathogens and resistance
pattern. J.Clin Pathol. 2010 Jul; 63(7):652-
Epub 2010 May 24.
Ava Behrooozi1, Mohammad Rahbar
and Jalil Vand Yousefi, A survey on epidemiology
of urinary tract infections and resistance
pattern of uropathogens in an Iranian1000-
bed tertiary care hospital, African
Journal of Microbiology Research Vol.
(9), pp. 753-756, 4 May, 2010
Rai GK, Upreti HC, Rai SK, Shah KP,
Shrestha RM. Causative agents of urinary
tract infections in children and their antibiotic
sensitivity pattern: a hospital based
study. Nepal Med Coll J. 2008
Jun;108680
Mohammed tariq et al E.coli urine
super bug and its antibiotic sensitivity, J.
Med. Sci. (Peshawar, Print) April-June
, Vol. 18, No. 2: 110-113
Yilmaz N, Agus N, Yurtsever SG,
Pulukcu H, Gulay Z, Coskuner A. et
al. Prevalence and antimicrobial susceptibility
of Escherichia coli in outpatient
urinary isolates in Izmir, Turkey.
Med Sci Monit 2009; 15: 161-65
Acar JF, Goldsein FW. Trends in
bacterial resistance to fluoroquinolones.
Clin Infect Dis 1997; 24
(Suppl): 67-73
Jalil A, Wadood A, Rehman JU,
Naseem R, Hussain A, Ali J. Comparative
susceptibilities of
Escherichia coli to ceftriaxone
alone and in combination with
sulbactam. Pak J Med Res 2005; 44:
-14.
Bertram G. Katzung, Susan
B .Masters, Anthony J. Trevor, Basic
and clinical pharmacology,11th edition,
Henry F. Chambers, Daniel
H.Deck, Beta-Lactam & Other cell
wall &membrane active antibiotics,
Abdollah karim, Mustafa sharifan
Microbial sensitivities in UTI Jpn. J.
Infect. Dis.2006 59,380-382
Dilnavaz shiek et al Med.J. Of Islamic
world academy of scinces 2005
; 4 129-133
Liana R. Merz, David K. Warren,
Marin H. Kollef, and Victoria J. Fraser,
Effects of an Antibiotic Cycling Program
on Antibiotic Prescribing Practices in an
Intensive Care Unit, antimicrobial agents
and chemotherapy, Aug. 2004, p. 2861–
I.W. Fong, Karl Drilca, Antimicrobial
resistance and implications for the 21st
century, Springer pub, p.371, 372
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