A STUDY OF THE ANTIBIOTIC SUSCEPTIBILITY PATTERN OF UROPATHOGENS ISOLATED FROM URINE CULTURES IN A TERTIARY CARE HOSPITAL IN TAMILNADU
Abstract
BACKGROUND -Urinary tract infection
(UTI) is one of the most common infections
affecting men and women of all ages.
The chronicity and complications of UTI
are important public health problems.
Since antibiotic resistance is on the rise
among uropathogens, it is important to
have local hospital based knowledge of
the organisms causing UTI and their antibiotic
sensitivity patterns to guide antibiotic
policy for rational and successful treatment.
OBJECTIVES- To retrospectively
study the growth pattern of uropathogens
isolated from urine culture samples and
their antibiotic susceptibility pattern for a
period of one month in a tertiary care hospital.
METHODS- This retrospective study
was conducted at the Institute of Microbiology,
Madras Medical College, Rajiv Gandhi
Govt. General Hospital, Chennai. In
this study, laboratory records of patients
showing positive urine culture over one
month period were collected. The age and
sex of the patients and the type of urinary
isolates and their antibiotic
susceptibility pattern were noted and analyzed.
RESULTS- Of the 540 samples collected
for the study (Males-42.2percent,
Females-57.8percent), the isolates found
were E.coli-45.9percent, Klebsiella-
23.7percent, others -30.4percent
(Citrobacter, Proteus, Pseudomonas,
Staphylococci, Acinetobacter, Enterococci).
Amikacin, Cefotaxime, Norfloxacin,
Gentamicin, Nitrofurantoin, Cotrimoxazole
were the most commonly tested drugs.
Most of the isolates showed sensitivity to
Amikacin (70.3percent) and Nitrofurantoin
(54.9percent). E.coli showed sensitivity to
Cefaperazone-sulbactum (78.4percent),
Amikacin (78percent), Nitrofurantoin
(60.9percent) and for Klebsiella it was
93.3percent, 62percent and 50.8percent
respectively. Overall, the organisms
showing resistance to Norfloxacin were
81.6percent, Cotrimoxazole-71.5percent,
Cefotaxime-66.4percent and Gentamicin-
60.2percent.Staphylococci and Proteus
showed resistance to all antibiotics except
to Amikacin. Enterococcus was sensitive
only to amoxicillin.CONCLUSION-High
level of
resistance by the common uropathogens is a
matter of concern as evidenced by this
study. This mandates periodic evaluation of
the culture pattern and their antibiograms to
guide the antibiotic policy to prevent emergence
of drug resistance
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