Cover Image

A STUDY OF THE ANTIBIOTIC SUSCEPTIBILITY PATTERN OF UROPATHOGENS ISOLATED FROM URINE CULTURES IN A TERTIARY CARE HOSPITAL IN TAMILNADU

SUGIRDA SUGIRDA

Abstract


BACKGROUND -Urinary tract infection
(UTI) is one of the most common infections
affecting men and women of all ages.
The chronicity and complications of UTI
are important public health problems.
Since antibiotic resistance is on the rise
among uropathogens, it is important to
have local hospital based knowledge of
the organisms causing UTI and their antibiotic
sensitivity patterns to guide antibiotic
policy for rational and successful treatment.
OBJECTIVES- To retrospectively
study the growth pattern of uropathogens
isolated from urine culture samples and
their antibiotic susceptibility pattern for a
period of one month in a tertiary care hospital.
METHODS- This retrospective study
was conducted at the Institute of Microbiology,
Madras Medical College, Rajiv Gandhi
Govt. General Hospital, Chennai. In
this study, laboratory records of patients
showing positive urine culture over one
month period were collected. The age and
sex of the patients and the type of urinary
isolates and their antibiotic
susceptibility pattern were noted and analyzed.
RESULTS- Of the 540 samples collected
for the study (Males-42.2percent,
Females-57.8percent), the isolates found
were E.coli-45.9percent, Klebsiella-
23.7percent, others -30.4percent
(Citrobacter, Proteus, Pseudomonas,
Staphylococci, Acinetobacter, Enterococci).
Amikacin, Cefotaxime, Norfloxacin,
Gentamicin, Nitrofurantoin, Cotrimoxazole
were the most commonly tested drugs.
Most of the isolates showed sensitivity to
Amikacin (70.3percent) and Nitrofurantoin
(54.9percent). E.coli showed sensitivity to
Cefaperazone-sulbactum (78.4percent),
Amikacin (78percent), Nitrofurantoin
(60.9percent) and for Klebsiella it was
93.3percent, 62percent and 50.8percent
respectively. Overall, the organisms
showing resistance to Norfloxacin were
81.6percent, Cotrimoxazole-71.5percent,
Cefotaxime-66.4percent and Gentamicin-
60.2percent.Staphylococci and Proteus
showed resistance to all antibiotics except
to Amikacin. Enterococcus was sensitive
only to amoxicillin.CONCLUSION-High
level of 

resistance by the common uropathogens is a
matter of concern as evidenced by this
study. This mandates periodic evaluation of
the culture pattern and their antibiograms to
guide the antibiotic policy to prevent emergence
of drug resistance


Full Text:

PDF

References


Hiep.T.Nguyen. Bacterial Infections of

the Urinary Tract. In: Emil A.Tanagho,

Jack W.McAninch, editors. Smith’s general

urology.16th ed. UcA:McGraw-

Hill;2004.p.203.

Bonadio, M., Meini, M., Spetaleri, P.

Gilgi, C. Current microbiological and clinical

aspects of urinary tract infections.

Eur. J. Urol.2001; 40:439-445.

Anthony J.Schaeffer, Edward

M.Schaeffer. Infections of the urinary

tract. In: Alan J. Wein, Louis R.

Kavoussi, Andrew C. Novick, Alan

W. Partin, and Craig A. Peters, editors.

Campbell-Walsh’s Urology. 9th

ed. Philadelphia PA : Saunders Elsevier.;

: p.223-239.

M.J. Saffar, A.A. Enayti, I.A. Abdolla,

M.S. Razai1 and H. Saffar. Antibacterial

susceptibility of uropathogens

in 3 hospitals, Sari, Islamic Republic

of Iran. Eastern Mediterranean

Health Journal.2008;14(3):556-562.

Mohammad Alzohairy and Habeeb

Khadri. Frequency and Antibiotic Susceptibility

Pattern of Uro-Pathogens

Isolated from Community and Hospital-

Acquired Infections in Saudi Arabia

– A Prospective Case Study. British

Journal of Medicine & Medical Research.

; 1(2): 45-56.

Krieger JN. Urinary tract infections:

what’s new? J Urol 2002; 168

(6): 2351-2358.

Monique Chomarat.Resistance

of bacteria in urinary tract infections.

International Journal of Antimicrobial

agents. 2000; 16(4):483-487.

M.J. Saffar, A.A. Enayti, I.A. Abdolla,

M.S. Razai1 and H. Saffar. Antibacterial

susceptibility of uropathogens

in 3 hospitals, Sari, Islamic Republic

Eastern Mediterranean Health Journal.2008;14

(3):556-562.

Mohammad Alzohairy and Habeeb

Khadri. Frequency and Antibiotic Susceptibility

Pattern of Uro-Pathogens Isolated

from Community and Hospital-Acquired Infections

in Saudi Arabia – A Prospective

Case Study. British Journal of Medicine &

Medical Research.2011; 1(2): 45-56.

Krieger JN. Urinary tract infections:

what’s new? J Urol 2002; 168(6): 2351-

Monique Chomarat.Resistance of bacteria

in urinary tract infections. International

Journal of Antimicrobial agents. 2000; 16

(4):483-487.

Getenet Beyene, Wondewosen Tsegaye.

Bacterial Uropathogens In Urinary

Tract Infection And Antibiotic Susceptibility

Pattern In Jimma University Specialized

Hospital, Southwest Ethiopia. Ethiop J

Health Sci.2011; 21(2):141-145.

Robert Orenstein, Edward S. Wong.

Urinary Tract Infections in Adults. Am Fam

Physician. 1999 Mar 1;59(5):1225-1234.

Ad C. Fluit, Mark E. Jones, Franz-Josef

Schmitz, Jacques Acar, Renu Gupta & Jan

Verhoef. Antimicrobial resistance among

urinary tract infection (UTI) isolates in

Europe: results from the SENTRY Antimicrobial

Surveillance Program 1997?Antonie

van Leeuwenhoek 2000;77: 147–152.

Atul Kothari, Vishal Sagar.Antibiotic resistance

in pathogens causing communityacquired

urinary tract infections in India: a

multicenter study.J Infect Developing Countries.

; 2(5):354-358.

Bhargavi P.S., Gopala Rao T.V.,

Mukkanti K., Dinesh Kumar B.,

Krishna T.P. Increasing emergence

of antibacterial resistance mainly in

uropathogens: Southeast part of India.

International Journal of Microbiology

Research.2010; 2(1): p.1-6

Azra S. Hasan, D. Nair, J Kaur,

G. Baweja, M Deb, P. Aggarwal.

Resistance patterns of urinary isolates

in a tertiary Indian hospital. J

Ayub Med Coll Abbottabad 2007; 19

(1):39-41.

Manjunath GN , Prakash R ,

Vamseedhar Annam , Kiran

Shetty.Changing trends in the spectrum

of antimicrobial drug resistance

pattern of uropathogens isolated

from hospitals and community patients

with urinary tract infections in

Tumkur and Bangalore. Int J Biol

Med Res. 2011; 2(2): 504 – 507.

Kalpana Gupta, Delia Scholes,

Walter E. Stamm. Increasing Prevalence

of Antimicrobial Resistance

Among Uropathogens Causing

Acute Uncomplicated Cystitis in

Women. JAMA, February 24,

;281(8):736-738.

K.R. Rajesh, S. Mathavi, R.Indra

Priyadarsini. Prevalence of Antimicrobial

Resistance in Uropathogens

and determining empirical therapy

for Urinary Tract Infections. International

Journal of Basic Medical Science.

;2(4)


Refbacks

  • There are currently no refbacks.


Creative Commons License
This work is licensed under a Creative Commons Attribution-NoDerivatives 4.0 International License.

An Initiative of The Tamil Nadu Dr M.G.R. Medical University