Evaluation of Antipyretic Effect of Azadirachcta indica Leaf Extract on Fever-Induced Albino Rats (Wistar)

Vijayalakshmi M .


OBJECTIVES - To evaluate Antipyretic Effect of Azadirachcta indica Leaf Extract on Fever-Induced Albino Rats (Wistar). MATERIALS AND METHODS - 30 adult male albino rats weighing 200-250 gm were selected and allocated into five roups of 6 animals each. The control group received normal feed and water, standard group received T.Aspirin and test group received ethanolic extract of Azadirachcta indica Leaf . Rectal temperature of the rats were taken before inducing pyrexia. Pyrexia induced by subcutaneous injection of aqueous suspension of backers yeast behind the ear. After 18 hrs of inducing pyrexia, rectal temperature recorded again. The extract was administered to group3,4 ,5 at graded doses of 100mg, 200mg, 300mgkg after the certification of fever. The temperature of the rats were taken at 60mts, 90mts120mts and then recorded. The findings were recorded, tabulated and a n a l y z e d w i t h s u i t a b l e s t a t i s t i c a l m e t h o d . RESULTS - Azadirachcta indica Leaf Extract has significant antipyretic effect. The results were comparable to that produced by standard drug aspirin.CONCLUSION - Azadiraccta indica Leaves has antipyretic effect which was comparable to aspirin. Keyword :Antipyretic, Backers yeast, Azadirachcta indica.

Full Text:



Roxburgh, W., 1874. Description of Indian Plants. Today and Tomorrow’s Printers and Publishers, New Delhi, India.

Singh, R.P., M.S. Chari, A.K. Raheja and W. Kraus, 1996. Neem and Sternberg E.M., Neuralimmune interaction in health and disease. J. Clin. Invest., 100: 2641-2647.

Basak, S.P. and D.P. Chakroborty, 1968. Chemical investigation of A. indica leaf (Melia azadirachta). J. India Chem. soc., 45: 466-467

Biswas, K., K. Chattopadhyay, R.K. Banerjee and U.Bandyopadhyay, 2002. Biological activities and medicinal properties of neem (Azadirachta indica).Curr. Sci., 82: 1336-1345.

Dascombe, M.J., 1985. The pharmacology of fever. Prog. Neuro Boil, 25: 327-373.

Adams, S.S., P. Hebborn and J.S. Nicholas, 1968. Some aspect of pharmacology of Ibufenac a non steroidal anti inflammatory agent. J. Pharm., 20: 305-312.

O.J. Olorunfemi et al. Evaluation of Anti-Inflammatory, Analgesic and Antipyretic Effects of Azadrichcta indica Leaf Extract on Fever-Induced Albino Rats (Wistar). British Journal of Pharmacology and Toxicology 3(2): 49-53, 2012

Chakraborty A, Devi BRK, Sanjebam R, Khumbong S, Thokchom IS. Preliminary studies on local anaesthetic and antipyretic activities of Spilanthes acmella Murr. In experimental animal models. Indian J Pharmacol, 2010; 42(5): 277-79.

Shukla P, Shukla P, Mishra SB, Gopalakrishna B. Screening of anti-inflammatory and antipyretic activity of Vitex Leucoxylon Linn. Indian J of Pharmacol, 2010;42(6): 409-11.


  • There are currently no refbacks.

Creative Commons License
This work is licensed under a Creative Commons Attribution-NoDerivatives 4.0 International License.

An Initiative of The Tamil Nadu Dr M.G.R. Medical University