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Short Term Effect Of Zinc On Major Blood Electrolytes In Wistar Rat

Pijush Kanti Bagchi .


: Zinc (Zn2) is an essential micronutrient of human body and Zn2 deficiency has been found to be associated with many diseases. It is also a potential therapeutic agent for a number of diseases. Studies have shown that some relationship exists between Zn2 levels and the major electrolyte concentration in blood, but the short term effect of Zn2 administration on major electrolytes has not been studied. This study aimed at finding the short term effect of parenteral Zn2 administration on blood levels of Sodium, Potassium and ionized Calcium. Towards this, 6 anaesthetized rats received single dose intraperitoneal Zn2 in the test group and 6 rats received Normal saline in the control group in a randomized way. Blood levels of these electrolytes at base line (zero hour) and after one, two and three hours post-intervention were compared between test and control group. The statistical analysis was done using Mann Whitney U test. Inter-group analysis of the electrolytes at zero, first, second and third hour did not show any significant difference between test and control group. We conclude that parenteral administration of Zn2 has no effect on the blood levels of major electrolytes and hence does not cause any electrolyte imbalance.

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