Quinolone resistance among uropathogens in a tertiary care centre

Preetthi A R .


Background objectives The resistance of bacteria causing urinary tract infections (UTI) to commonly prescribed antibiotics is increasing both in developing as well as in developed countries. Resistance has emerged even to more potent antimicrobial agents. The present study was undertaken to report the quinolone resistance among the uropathogens isolated in a tertiary care centre in south India.Methodology A total of 1431 consecutive urine samples were cultured in Department of Microbiology, from August to October 2014 and pathogens isolated were identified by standard methods. Antibiotic susceptibility was done by Kirby Bauer disc diffusion method to quionolones. The patients age, sex and admission status were also observed. Results Of the 1431 samples, 341 showed growth. Females were frequently infected and adults were mostly affected than children. Inpatients were commonly infected than outpatients. Escherichia coli (64.2) was the most common organism isolated followed by Klebsiella species (26.1). Overall resistance of organisms to Quinolones were Norfloxacin (67.5), Ofloxacin (42.8) and Ciprofloxacin(41.5) Conclusion - This study indicates the emerging quinolone resistance among the bacterial pathogens of UTI which may be due to its frequent use. Hence our study indicates that it is imperative to rationalize the use of quinolones in the community and also to use them conservatively.

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