Cover Image

Secretory carcinoma of breast-a rare case report

Supasakthi S .


Secretory carcinoma of breast is a rare histological variant of breast carcinoma with an incidence of 0.15. It is relatively more common in the first three decades of life with median age of 23 years. However it is reported in adults of both sexes. In our institution, a 58 year old female, presented with history of lump in the right breast for 2 years and with pain and ulceration for past six months. Modified radical mastectomy was done. Histopathological examination showed a malignant tumour with microcystic and tubuloalveolar pattern and irregular microlumens containing eosinophilic secretions. Intracytoplasmic and intraluminal secretions showed Periodic Acid Schiff positivity. Immunohistochemistry for Estrogen receptor, Progesterone Receptor and Her 2-neu were negative (triple negative). It was a case of secretory carcinoma of breast. It is a unique, triple negative breast carcinoma ,with indolent clinical behavior, late local recurrences and prolonged survival, even with lymph node metastasis.

Full Text:



Tavassoli FA, Norris HJ. Secretory carcinoma of the breast. Cancer 1980;45:2404–2413.

Serour F, Gilad A, Kopolovic J, et al. Secretory breast cancer in childhood and adolescence: report of a case and review of the literature. Med Pediatr Oncol 1992;20:341–344.

C. Tognon, S. R. Knezevich, D. Huntsman et al., “Expression of the ETV6-NTRK3 gene fusion as a primary event in human secretory breast carcinoma,” Cancer Cell, vol. 2, no.5, pp. 367–376, 2002

Rosen PP. Secretory carcinoma. In: Rosen’s Breast Pathology. 3rd ed. Philadelphia, PA: Lippincott Williams and Wilkins; 2009:563–570

Anderson P, Albarracin CT, Resetkova E. A large, fungating breast mass:secretory carcinoma with apocrine differentiation. Arch Pathol Lab Med. 2006;130(4):50–52.

Laé M, Fréneaux P, Sastre-Garau X, et al. Secretory breast carcinomas with ETV6-NTRK3 fusion gene belong to the basal-like carcinoma spectrum. Mod Pathol 2009;22:291–298

Livasy CA, Karaca G, Nanda R, et al. Phenotypic evaluation of the basal-like subtype of invasive breast carcinoma. Mod Pathol 2006;19:264–271.

Tixier H, Picard A, Guiu S, et al. Long-term recurrence of secretory breast carcinoma with metastatic sentinel lymph nodes. Arch Gynecol Obstet 2011;283(Suppl 1): 77–78.

Vieni S, Cabibi D, Cipolla C, et al .Secretory breast carcinoma with metastatic sentinel lymph node. World J Surg Oncol 2006;4:88

Fadare O, Tavassoli FA. Clinical and pathologic aspects of basal-like breast cancers. Nat Clin Pract Oncol 2008;5: 149–159.


  • There are currently no refbacks.

Creative Commons License
This work is licensed under a Creative Commons Attribution-NoDerivatives 4.0 International License.

An Initiative of The Tamil Nadu Dr M.G.R. Medical University