University Journal of Pre and Paraclinical Sciences
Bacteriological Profile and Antibiogram Pattern of Neonatal Sepsis with special reference to ESBL producing Klebsiella pneumoniae in a Tertiary Care Hospital.
Abstract
Objectives To determine the bacteriological
profile and to evaluate the antimicrobial
susceptibility pattern of organisms isolated
from neonatal septicemia to initiate early
effective antibiotic therapy and to detect
the ESBL producer in predominant Gram
Negative isolate Klebsiella pneumoniae.
Methods This is a cross sectional study of
100 babies suspected of neonatal sepsis
based on clinical diagnosis. After isolating
and identifying the organisms from blood
culture antimicrobial susceptibility was
done as per CLSI guidelines. Among the
Gram negative bacilli ESBL producing
Klebsiella pneumoniae were identified. Results
culture positivity was 46, out of which
GPC constitute 60.87 where as GNB constitute
39.13. Among the predominant
Gram negative bacterial isolates 46 were
ESBL producers. Conclusion This study
revealed blood cultures are mandatory in
all neonatal septic cases for seeking specific
sensitivity patterns and accordingly
modifying the antibiotic therapy
Keyword :Neonatal septicemia, ESBL,
Klebsiella pneumoniae.
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