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COMPARISON OF MEASUREMENT OF LDL-C - CALCULATED Vs DIRECT ASSAYS

SIVA SOMANA J

Abstract


Serum LDL-C is an independent modifiable risk  factor for coronary heart disease and it is the major criterion for diagnosis and treatment of patients with Hyperlipidemia.  LDL-C measurement done by Enzymatic Colorimetric assays and Friedewalds Formula in 130 fasting blood samples.   Statistical analysis suggests that the reliability of Calculated  LDL-C estimation decreases considerably with increase in the TAG levels. With TAG levels 400mgdl, Cholesterol is                overestimated by Friedewald's calculation resulting in  under-estimated LDL-C values and therefore the need for direct method comes in clinical application.

 


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References


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