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RASMUSSENS ENCEPHALITIS A CASE REPORT

SHOBANA U

Abstract


We report a case of Rasmussens Encephalitis . It is a rare chronic inflammatory neurological disease of unknown origin. It usually affects only one hemisphere. It is uncommon in adults. Rasmussens Encephalitis is characterized by intractable severe seizures, loss of motor skills and speech, paralysis on one side of the body Our case is a three year old male child referred from neurology department with complaint of intractable seizures, progressive hemiparesis, and deteriorated cognition following an episode of encephalitis. He showed a classical clinical presentation of focal seizures and left sided weakness since ten month of age. CT Brain taken at ten months of age was normal . Follow up MRI Brain done in April 2015 showed mild unilateral right cerebral hemisphere atrophic changes. T2 and FLAIR hyperintensity involving right hemisphere also seen. After three months follow up MRI done in July 2015 year showed progressive increase in hemispheric atrophy and signal changes involving right hemisphere that further support the diagnosis of Rasmussens Encephalitis.

 


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References


Diagnostic imaging Brain Osborn –Blaser. Salzman. Katzman. Provenzale

Rasmussen T olzewski J,LloydSmith D.Focal seizures due to chronic localized encephalitis.Neurology.

Oguni H, Andermann F, Rasmussen T (1991) The natural history of the syndrome of chronic encephalitis and epilepsy: a study of the MNI series of forty-eight cases. Chronic encephalitis and epilepsy Rasmussen’s syndrome Boston: Butterworth-Heinemann: 7-35.

Bauer J, Elger CE, Hans VH, Schramm J, Urbach H, et al. (2007) Astrocytes are a specific immunological target in Rasmussen's encephalitis. Ann Neurol 62: 67-80.

Schwab N, Bien CG, Waschbisch A, Becker A, Vince GH, et al. (2009) CD8+ T-cell clones dominate brain infiltrates in Rasmussen encephalitis and persist in the periphery. Brain 132: 1236- 1246.

Granata T, Cross H, Theodore W, Avanzini G (2011) Immune-mediated epilepsies. Epilepsia 52 Suppl 3: 5-11..

Granata T, Gobbi G, Spreafico R, Vigevano F, Capovilla G, et al. (2003) Rasmussen's encephalitis: early characteristics allow diagnosis. Neurology 60: 422-425.

Bien CG, Schramm J (2009) Treatment of Rasmussen encephalitis half a century after its initial description: promising prospects and a dilemma. Epilepsy Res 86: 101-112.

Bahi-Buisson N, Villanueva V, Bulteau C, Delalande O, Dulac O, et al. (2007) Long term response to steroid therapy in Rasmussen encephalitis. Seizure 16: 485-492.

Marras CE, Granata T, Franzini A, Freri E, Villani F, et al. (2010) Hemispherotomy and functional hemispherectomy: indications and outcome. Epilepsy Res 89: 104-112.


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