A Study of Serum Ghrelin Levels in Obese Individuals
Abstract
Background Obesity is a common nutritional problem faced by world today. The common causes of obesity are sedentary life, improper eating habits, stress, smoking, alcoholism apart from genetically determined factors. Obesity is a proved risk factor in atherosclerosis, CHD, stroke, sleep apnoea, and numerous malignancies. Ghrelin is a hunger hormone and its levels vary physiologically with appetite and satiety. Aim To study and analyse the serum level of ghrelin levels in obese individuals. Methods The study includes randomly selected (equal male and female) 30 controls and 30 obese individuals. Age group of the individuals lie between 20- 50 years. Individuals with epilepsy, diabetic, endocrine dysfunction, known cardiovascular or GI problems were excluded from the study. Results The results showed no significant sex difference in the serum ghrelin levels (p 0.05). Serum ghrelin levels are reduced significantly with p value 0.000 in obese. Conclusion Serum Ghrelin levels are significantly reduced in obese individuals irrespective of sex.
Full Text:
PDFReferences
Howard AD, Cully DF, Arena JP, Liberator PA, Rosenblum CI, Hamelin M, Anderson J, Paress PS, Diaz C, Chou M, Liu KK, McKee KK, Pong SS, Griffin PR, A, Gupta SK, Schaeffer JM, Smith RG, Vander Ploeg LH (August 1996) "A receptor in pituitary and hypothalamus that functions in growth hormone release".
Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K (1999). "Ghrelin is a growthhormone- releasing acylated peptide from stomach". Nature 402 (6762): 656–60.
Wren, A.M Ghrelin causes hyperphagia and obesity in rats.2001
Circulating Ghrelin Levels Are Decreased in Human Obesity Matthias Tschöp, Christian Weyer, P. Antonio Tataranni, Viswanath Devanarayan, Eric Ravussin and Mark L. Heiman.
Refbacks
- There are currently no refbacks.
This work is licensed under a Creative Commons Attribution-NoDerivatives 4.0 International License.
An Initiative of The Tamil Nadu Dr M.G.R. Medical University