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EVALUATION OF COGNITIVE FUNCTION IN CHILDREN WITH ATTENTION DEFICIT HYPERACTIVITY DISORDER BY USING AUDITORY EVENT RELATED POTENTIALS

ANITHA PONMALAR J

Abstract


Background Aim - Attention deficit hyperactivity  disorder (ADHD) is a childhood disorder characterized by lack of sustained attention, hyperactivity and impulsivity. Recording of Event- related potentials from the scalp is a non-invasive           technique reflecting the sensory and cognitive processes           associated with tasks involving attention. The aim of the present study is to assess the difference in cognitive function between normal and ADHD children using Auditory Event Related           Potentials (ERP). Methods - Thirty ADHD children and 30            controls were recruited for the study. Auditory ERPs (N100, P200, N200 and P300) were recorded using auditory oddball paradigm at Pz on a computerized evoked potential recorder, after placement of electrodes using the international 10-20   system of electrode placement. Results - The ADHD children showed a statistically significant decrease in P 300 amplitude and prolongation of P 300 latency compared with the controls. When divided into two age groups, P300 latency was                     significantly increased in both the age groups and a smaller P300 amplitude was found in ADHD children less than 10 years of age. Conclusion - Prolonged latency of P300 shows slowing of auditory processing and decrease in P300 amplitude                suggests disruption of inhibitory control in children with ADHD. These results suggest a neurocognitive abnormality in children with ADHD as indicated by ERP response.

 


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References


American Psychiatric Association. DSM-IV. Diagnostic and Statistical Manual of Mental Disorders, (4th ed.). Washington, DC; American Psychiatric Association 1994.

Rubia K.ADHD: What have we learned from Neuro-imaging? Cutting edge psychiatry in practice (CEPIP). 2012; 1: 16-19.

Valera EM, Faraone SV, Murray KE, Seidman LJ. Meta-analysis of structural imaging findings in attentiondeficit/ hyperactivity disorder. Biol Psychiatry. 2007; 61(12) : 1361-1369.

Douglas DI. Cognitive control processes in attention-deficit/hyperactivitydisorder.In:Quay HC, Hogan AE,editors.Handbook of disruptive behavior disorders. New York: Kluwer Academic Publishers/Plenum Press, 1999: 105-55.

Romani A, Conte S, Callieco R et al. Visual evoked potential abnormalities in dyslexic children. Funct Neurol 2001; 16: 219-229.

Booth JR, Burman DD, Meyer JR, Lei Z, Trommer BL, Davenport ND et al.(2005). Larger deficits in brain networks for response inhibition than for visual selective attention in attention deficit hyperactivity disorder(ADHD). J Child Psychol Psychiatry 46:94-111.

Goodin DS. Event-related (endogenous) potentials. In: Aminoff MJ ed Electrodiagnosis in Clinical Neurology (3rd ed.). New York; Churchill Livingstone 1992:627-648.

Picton TW, Hillyard SA. Human auditory potentials: II. Effects of attention. Electroencephalogr Clin Neurophysiol 1974;36:191-199.

Ritter W, Ford JM, Gaillard AW et al. Cognition and event-related potentials. I. The relation of negative potentials and cognitive processes: Ann NY Acad Sci 1984;425:24-38.

Smith ME, Halgren E, Sokolik M et al. The intracranial topography of the P3 event related potential elicited during auditory oddball. Electroencephalogr Clin Neurophysiol 1990;76:235-248.

Hillyard SA. Cognitive functions and event-related brain potential. In: Nodar RH, Barber C, editors. Evoked potentials

II. Stoneham, MA: Butterworth, 1984:51-62.

Satterfield JH, Schell AM, Nicholas TW, Satterfield BT, Freese TE. Ontogeny of selective attention effects on eventrelated potentials in attention-deficit hyperactivity disorder and normal boys. Biol Psychiatry 1990;28:879-903.

Kutas M, McCarthy G, Donchin E. Augmenting mental chronometry: the P300 as a measure of stimulus evaluation.

Science 1977;197:792-5.

Kemner C, Verbaten MN, Koelega HS, Camfferman G, van Engeland H. Are abnormal event-related potentials specific to children with ADHD? A comparison with two clinical groups. Percept Mot Skills 1998;85:1083-90.

Kahn I, Davachi L, Wagner AD (2004). Functional – neuroanatomic correlates of recollection: implications for models of recognition memory. J Neurosci 24:4172-4180.

Lazzaro I, Gordon E, Whitmont S, Meares R, Clarke S. The modulation of late component event related potentials by

pre-stimulus EEG theta activity in ADHD. Int J Neurosci 2001;107:247-264.

Sunohara GA, Malone MA, Rovet J, Humphries T, Roberts W, Taylor MJ. Effect of methylphenidate on attention in children with attention deficit hyperactivity disorder (ADHD): ERP evidence. Neuropsychopharmacology 1999;21:218- 228.

Puente A, Ysunza A, Pamplona M, Silva-Rojas A, Lara C. Short latency and long latency auditory evoked responses

in children with attention deficit disorder. Int J Pediatr Otorhinolaryngol 2002;62:45-51.

Jonkman LM, Kemner C, Verbaten MN, Koelega HS, Camfferman G, Gaag R, et al.(1997). Event-related potentials and performance of attention-deficit hyperactivity disorder: children and normal controls in auditory and visual selective attention tasks.Biol Psychiatry41:595-611.

Idiazábal Alecha M, Palencia Taboada AB, Sangorrín J, Espadaler-Gamissans JM. Cognitive evoked potentials in the hyperactivity attention deficit disorder. Rev Neurol 2002;34: 301-305

Barry RJ, Johnstone SJ, Clarke AR (2003). A review of electrophysiology in attention-deficit/hyperactivity disorder: II. Event-related potentials. Clin Neurophysiol 114:184-198.

Hoeksma MR, Kemner C, Kenemans JL, Van Engeland H(2006). Abnormal selective attention normalizes P3 amplitudes in PDD. J Autism Dev Disord 36:643-654.

Pliszka SR, Liotti M, Woldorff MG. Inhibitory control in children with attention-deficit/hyperactivity disorder: eventrelated potentials identify the processing component and timing of an impaired right-frontal response-inhibition mechanism. Biol Psychiatry 2000; 48:238-246.

Loiselle DL, Stamm JS, Maitinsky S, Whipple SC. Evoked potential and behavioral signs of attentive dysfunctions in hyperactive boys. Psychophysiology 1980; 17: 193-201.

Asmaa Abdel-Hamid, Rasha Safwat, Omnia Raafat, Hani Hamed and AyaAllah Farouk. Central auditory processing and audio-vocal psycholinguistic abilities in children with attention deficit-hyperactivity disorder: Egyptian Journal of Psychiatry, 2013, 34:98-103.

Min-Lan Tsai, Kun-Long Hung, Hui-Hua Lu. Auditory Event-related Potentials in Children with Attention Deficit Hyperactivity Disorder: Pediatrics and Neonatology (2012) 53, 118-124.

Yumnam Anjana, MD, Farah Khaliq, MD, Neelam Vaney, MD. Event-related potentials study in attention deficit hyperactivity disorder. Functional neurology 01/2010; 25(2):87-92.

Rothenberger A, Banaschewski T, Heinrich H, Moll GH, Schmidt MH, Van’t Klooster B (2000). Comorbidity in ADHD children: effects of coexisting conduct disorder or tic disorder on event-related brain potentials in an auditory selective-attention task. Eur Arch Psychiatry Clin Neurosci 250:101-110.


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