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COMPARATIVE ANALYSIS OF VARIOUS STEM CELLS AS NOVEL CANDIDATES FOR NEURONAL REGENERATIVE THERAPY

AVINASH THAKUR

Abstract


For the last few decades researchers have found many number of potential pleuripotent stem cells which could be used in tissue regenerating therapies. But yet the unanswered question remains that which one of them is the most ideal           candidate for cell based therapy in central nervous system  repair. The ideal stem cell for use in functional tissue                   engineering needs to be abundantly available, harvested with minimal morbidity, shows plasticity, able to easily survive and interact with the host and is able to be transplanted safely and efficaciously. This article reviews some of the commonly used stem cells like epidermal stem cells, olfactory epithelial stem cells, hematopoietic stem cells and adipocyte derived stem cells in central nervous system repair and compares their                      effectiveness and shortcomings.

 


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References


(1) G. J. Brewer. “Regeneration and proliferation of embryonic and adult rat hippocampal neurons in culture.” Exp. Neurol., 159, No. 1, 237-247 (1999)

(2) Vierbuchen T, Ostermeier A, Pang ZP, Kokubu Y, Südhof TC, Wernig M. Direct conversion of fibroblasts to functional neurons by defined factors. Nature. 2010 Feb 25;463(7284):1035-1041.

(3) Schäffler A, Büchler C. Concise review: adipose tissue-derived stromal cells--basic and clinical implications for novel cell-based therapies. Stem Cells. 2007 Apr;25(4): 818-827.

(4) Weisberg SP, McCann D, Desai M et al. Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest 2003;112: 1796–1808.

(5) Xu H, Barnes GT, Yang Q et al. Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest 2003;112:1821–1830.

(6) Caspar-Bauguil S, Cousin B, Galinier A et al. Adipose tissues as an ancestral immune organ: Sitespecific change in obesity. FEBS Lett 2005;579:3487–3492.

(7) Prunet-Marcassus B, Cousin B, Caton D et al. From heterogeneity to plasticity in adipose tissues: Site-specific differences. Exp Cell Res 2006;312:727–736.

(8) Casteilla L, Planat-Benard V, Cousin B et al. Plasticity of adipose tissue: A promising therapeutic avenue in the treatment of cardiovascular and blood diseases. Arch Mal Coeur Vaiss 2005;98:922–926.

(9) Zuk PA, Zhu M, Ashjian P et al. Human adipose tissue is a source of multipotent stem cells. Mol Biol Cell 2002; 13:4279–4295.

(10) Katz AJ, Tholpady A, Tholpady SS et al. Cell surface and transcriptional characterization of human adipose-derived

adherent stromal (hADAS) cells. STEM CELLS 2005;23:412– 423.

(11) Oedayrajsingh-Varma M, van Ham S, Knippenberg M et al. Adipose tissue-derived mesenchymal stem cell yield and growth characteristics are affected by the tissue-harvesting procedure. Cytotherapy 2006;8: 166–177.

(12) Izadpanah R, Trygg C, Patel B et al. Biologic properties of mesenchymal stem cells derived from bone marrow and adipose tissue. J Cell Biochem 2006;99:1285–1297.

(13) Romanov YA, Darevskaya AN, Merzlikina NV et al. Mesenchymal stem cells from human bone marrow and adipose tissue: Isolation, characterization, and differentiation potentialities. Bull Exp Biol Med 2005;140:138 –143.

(14) Safford KM, Hicok KC, Safford SD et al. Neurogenic differentiation of murine and human adipose-derived stromal cells. Biochem Biophys Res Commun 2002;294:371–379.

(15) Jun ES, Lee TH, Cho HH et al. Expression of telomerase extends longevity and enhances differentiation in human adipose tissue-derived stromal cells. Cell Physiol Biochem 2004;14:261–268.

(16) Kang SK, Lee DH, Bae YC et al. Improvement of neurological deficits by intracerebral transplantation of human adipose tissue-derived stromal cells after cerebral ischemia in rats. Exp Neurol 2003;183:355–366.

(17) Lagasse E, Connors H, Al-Dhalimy M, et al. Purified hematopoietic stem cells can differentiate into hepatocytes in vivo. Nat Med. 2000;6:1229-1234.

(18) Orlic D, Kajstura J, Chimenti S, et al. Bone marrow cells regenerate infarcted myocardium. Nature. 2001;410:701-705.

(19) A. Ramon-Cueto, F. Valverde. “Olfactory bulb ensheathing glia: a unique cell type with axonal growth-promoting properties.” Glia 14 163– 173(1995)

(20) Jang W, Lambropoulos J, Woo JK, Peluso CE, Schwob JE. “Maintaining epitheliopoietic potency when culturing olfactory progenitors.” Exp Neurol.;214(1):25-36 (2008 Nov)

(21) M. Caggiano, J.S. Kauer, D.D. Hunter. “Globose basal cells are neuronal progenitors in the olfactory epithelium: a lineage analysis using a replication-incompetent retrovirus.” Neuron 13 339– 352 (1994)


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