Immunohistochemical expression of Ki 67 in low grade lesions of cervix diagnosed by colposcopy.

Abstract

The basic elements in the development of
cancer including cervical cancer and its
precursors are uncontrolled cell proliferation
and malignant transformation. Precancerous
lesions of cervix are easily detectable
and treatable. Population based cervical
screening with the help of Pap smear,
colposcopic screening with biopsies and
LLETZ procedure for treatment has substantially
reduced the incidence of cervical
cancer. Many a time low grade lesions diagnosed
clinically does not correlate with
morphology. Ki67 a proliferative index
marker is a useful tool in identifying the
proliferation of cells at an early stage.
Hence this study aimed at finding out the
utility of Ki67 a proliferative index marker
in clinically discordant cases where the
colposcopy diagnosis was LSIL and histopathology
was chronic cervicitis with
squamous metaplasia. In our study 834
cases reported as chronic cervicitis with
squamous metaplasia over a period of
6months had a high proliferative index
score with Ki67 indicating that around 23.5
of cases go unnoticed on routine light microscopy.
This inference from our study stresses the
importance of running a proliferative index
marker on a routine basis in clinically suspected
low grade lesions even in population
based screening to reduce the cancer
burden.