BONE MARROW PATHOLOGY IN PANCYTOPENIA
Abstract
ObjectivePancytopenia is a common hematological
problem. It is the simultaneous
presence of a decreased RBC, WBC
platelet count. Many disorders can cause
pancytopenia. Theaim of this study is to
compare retrospectively, the incidence of
the underlying pathology in the bonemarrow
in cases presenting with pancytopenia
at our college.Materials and methods-
Hundred casesof pancytopenia were included
in the study over a period of two
years in the department of pathology.
Results -
Majority of the patients fall in the age
group of 20-60yrs. The most common
cause ofpancytopenia as elicited by bone
marrow study was Megaloblastic anemia
followed by dimorphicanemia, Iron deficiency
anemia, Acute leukemia, Aplastic
anemia, myeloma, malarial infection,
lymphoma, refractory cytopenia with
multilineage dyslasia, metastatic carcinomatous
deposits, HIVwith cryptococcal infection
drug induced pancytopenia were
less common causes.
Full Text:
PDFReferences
Rahim F, Ahmad I, Islam S, Hussain
M, Khattak TAK, Bano Q. Spectrum of
hematological disorders in children observed
in 424 consecutive bone marrow
aspirations/biopsies. Pak J Med Sci
;21:433-6.
Mussarat N, Raziq F. The incidence of
underlying pathology in pancytopenia.
An experience of 89 cases. J Postgr Med
Inst. 2004;18(1):76-9.
Ng SC, Kuperan P,Chan KS, Bosco
J,Chan G L, Magaloblastic anemia-A review
from University Hospital, Kuala
Lumpur, Ann Acad Med Sing 1988
:261.
Savage D G, Allen R H, Gangaidzo IT,
Levy LM, Gwanzura C, Moyo A et al.
Pancytopenia in Zimbabwe. Am J Med
Sci 1999 Jan 317:22-32
Kumar R, Kaira SP, Kumar H, Anand
AC, Madan H. Pancytopenia--a
six year study.J Assoc.Phys.India
; 49 :1078-81
Santra G, Das BK. A cross sectional
study of the clinical profile &
etiological spectrum of Pancytopenia
in a tertiary care centre. Singapore
Med J. 2010 Oct; 51(10):806-12.
Lequit RJ, van den Tweel JG. The
Pathology of Bone Marrow failure.
Histopathology 2010 Nov; 57(5):655-
Brunning RD , Bennett JM , Matutes
E, Orazi A, Vardiman JW,Thiele
J. Refractory cytopenia with multilineage
dysplasia. In: Steven H. Swerdlow,
Elias Campo, Nancy Lee Harris,
editors.World Health Organisation
Classification of Tumors. 4th edition.
France: Participe Present; 2008: 98-
Kumar S, Rau AR, Naik R, Kini H,
Mathai AM, Pai MR, Khadilkar UN.
Bone marrow biopsy in non-Hodgkin
lymphoma: A morphological study.
Indian J Pathol Microbiol
;52:332-8.
Frank A, Christine K, Edeltraut G.
Systematic Review: Agranulocytosis
Induced by Nonchemotherapy
Drugs . Ann Intern Med. 2007;146:6
Refbacks
- There are currently no refbacks.
This work is licensed under a Creative Commons Attribution-NoDerivatives 4.0 International License.
An Initiative of The Tamil Nadu Dr M.G.R. Medical University