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DIAGNOSTIC CHALLENGES IN SPINAL TUBERCULOSIS AND ROLE OF GENEXPERT

NAVEEN S .

Abstract


Spinal tuberculosis is a common form of extrapulmonary tuberculosis which can lead to profound   vertebral destruction and severe complications. Gene Xpert study a cartridge based fully automated test which can  simultaneously detect TB and rifampicin resistance within few hours is very useful in the early diagnosis of tuberculosis. Confirmation of the diagnosis of tuberculosis could be made in a majority of patients using the Genexpert study along with HPE. GeneXpert, tissue diagnosis, culture should form part of  diagnostic workup of spinal TB.

 


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References


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WHO. Molecular line probe assays for rapid screening of patients at risk of multidrug resistant tuberculosis (MDR-TB). Geneva: World Health Organisation; 2008.

Pai M, Minion J, Sohn H, et al. Novel and improved technologies for tuberculosis diagnosis: progress and challenges. Clin Chest Med 2009; 30: 701-716. A critical review of new TB diagnostics


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