A rare case of Combined Protein C and Protein S deficiency Manifesting as Cortical venous thrombosis.
Abstract
Protein C deficiency is a rare disorder that usually presents with purpura fulminans in the neonatal period ,disseminated intravascular coagulation and recurrent thrombotic episodes at a later age. Protein S deficiency is very rare. The annual incidence of cerebrovascular disease in children is 2.5 per 100,000 and cerebral infarction is being increasingly recognised in neonates. Here we see a case report of 11 months old child with combined Protein C and S deficiency presenting with hemiplegia due to Cortical venous thrombosis.
Full Text:
PDFReferences
Seligsohn U, Berger A, Abend M, Rubin L, Attias D, Zivelin A, Rapaport SI. Homozygous protein C deficiency manifested by massive venous thrombosis in the newborn. N Engl J Med. 1984 Mar 1;310(9):559–562. [PubMed]
Tarras S, Gadia C, Meister L, Roldan E, Gregorios JB. Homozygous protein C deficiency in a newborn. Clinicopathologic correlation. Arch Neurol. 1988 Feb;45(2):214–216. [PubMed]
Griffin JH, Evatt B, Zimmerman TS, Kleiss AJ, Wideman C. Deficiency of protein C in congenital thrombotic disease. J Clin Invest 1981; 68: 1370
Estelles A, Garcia-Plaza I, Dasi A et al. Severe inherited "homozygous" protein C deficiency in a newborn infant. Thromb Haemost 1984; 52: 53–6.
Dahlbäck B. The protein C anticoagulant system: inherited defects as basis for venous thrombosis. Thromb Res 1995; 77: 1–43
Nagesh Kumar TC, Kenchappa R, Kempegowda MB, Kulkarni A. Protein S deficiency in a case of superor sagital vein thrombosis. Indian J Med Sci 2011;65:36
Refbacks
- There are currently no refbacks.
This work is licensed under a Creative Commons Attribution-NoDerivatives 4.0 International License.
An initiative of The Tamil Nadu Dr M.G.R. Medical University